The Prophylactic Effects of Folic Acid and Vitamin E against Valproic Acid During Fetal Thymus Development: an Ultrastructural Study

Basit Öğe Kaydı
dc.contributor.authorBaran, Ozlem Pamukcu
dc.contributor.authorTunik, Selcuk
dc.contributor.authorAkkoc, Hasan
dc.contributor.authorDevieci, Engin
dc.contributor.authorAyaz, Ercan
dc.contributor.authorSoker, Sevda
dc.contributor.authorTas, Sevgi Kalkanli
dc.date.accessioned2024-04-24T17:24:10Z
dc.date.available2024-04-24T17:24:10Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractTo evaluate histopathologic differences in the thymus of Wistar Albino rat fetuses prenatally exposed to valproic acid (VPA), folic acid (FA) and vitamin E (Vit-E). VPA (400 mg/kg), FA (400 mcg/kg) and Vit -E (250 mg/kg) were administered to rats on each of gestation days 8,9 and 10. The fetuses (n:24) were divided into four groups: control, VPA, VPA+Vit-E and VPA+FA groups. On the 20th day of gestation, all pregnant rats were sacrificed and the fetuses were extracted. Thin sections from thymus of live fetuses were stained with uranyl acetate-lead citrate and were examined under transmission electron microscope. The histopathological findings of control group was normal. In VPA group, it showed extensive degenerative changes by VPA were on all tissue compartments when compared to controls. In VPA-FA group, vacuoles, mitochondrial cristalysis and swelling were decreased in cytoplasm. In VPA-Vit-E group, lipid storage and vacuolization were observed. Mitochondrial cristalysis decreased. Our aim in the present study is to analyze histopathological changes which may occur in a high risk experimental model after giving of VPA. In addition, protective roles of the administration of FA and Vit-E are assessed.en_US
dc.identifier.doi10.4067/S0717-95022011000400003
dc.identifier.endpage1098en_US
dc.identifier.issn0717-9502
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84858790232
dc.identifier.scopusqualityQ3
dc.identifier.startpage1093en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022011000400003
dc.identifier.urihttps://hdl.handle.net/11468/19478
dc.identifier.volume29en_US
dc.identifier.wosWOS:000302190500003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectValproic Aciden_US
dc.subjectFetal Thymusen_US
dc.subjectVitamin Een_US
dc.subjectFolic Aciden_US
dc.titleThe Prophylactic Effects of Folic Acid and Vitamin E against Valproic Acid During Fetal Thymus Development: an Ultrastructural Studyen_US
dc.titleThe Prophylactic Effects of Folic Acid and Vitamin E against Valproic Acid During Fetal Thymus Development: an Ultrastructural Study
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu