Effects of Major Depressive Disorder on monocytes, High-Density Lipoprotein (LDL) and monocyte to HDL ratio: A case-control study

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dc.authorid0000-0002-6428-1097en_US
dc.authorid0000-0002-8547-4111en_US
dc.contributor.authorUyar, Betül
dc.contributor.authorBudak, Elif Ateş
dc.date.accessioned2023-08-04T07:07:05Z
dc.date.available2023-08-04T07:07:05Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective: In this study, we investigated the effects of Major Depressive Disorder (MDD) on monocyte counts, High-Density Lipoprotein (HDL) levels, and Monocyte to HDL ratios (MHR) among inflammatory markers. Method: This is a retrospective case-control study. The case group of our study included 120 major depressive patients. The control group included 124 healthy individuals. The data were collected using a Personal Information Form, the Clinical Global Impression Scale, and the Hamilton Depression Rating Scale. The lipid profiles and complete blood count parameters of the case and control groups were tested and compared. The collected data were analyzed using the Kruskal-Wallis test, Mann-Whitney U test and independent-samples t-test. Results: A significant increase in the monocyte and MHR values and a decrease in the HDL values of the case group were observed with older ages (p<0.01). In the case group, the MHR and monocyte count values were higher, and the HDL levels were lower in the MDD patients who had never received treatment in comparison to those who had received treatment. As the severity of depression increased, MHR levels also increased. Conclusion: Our study is the first study to show that MHR is significantly higher in MDD patients than healthy controls. It was also shown that depression severity and MHR are positively correlated. Consequently, MHR might be a simple, practical, and lowcost parameter which shows inflammation in MDD patients.en_US
dc.identifier.citationUyar, B. ve Budak, E. A. (2022). Effects of Major Depressive Disorder on monocytes, High-Density Lipoprotein (LDL) and monocyte to HDL ratio: A case-control study. Psychiatria Danubina, 33(4), 687-694.en_US
dc.identifier.doi10.24869/PSYD.2022.687
dc.identifier.endpage694en_US
dc.identifier.issn0353-5053
dc.identifier.issue4en_US
dc.identifier.pmid36548882
dc.identifier.scopus2-s2.0-85144523026
dc.identifier.scopusqualityQ3
dc.identifier.startpage687en_US
dc.identifier.urihttps://www.psychiatria-danubina.com/
dc.identifier.urihttps://hdl.handle.net/11468/12425
dc.identifier.volume33en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUyar, Betül
dc.institutionauthorBudak, Elif Ateş
dc.language.isoenen_US
dc.publisherMedicinska Naklada Zagreben_US
dc.relation.ispartofPsychiatria Danubina
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMajor Depressive Disorderen_US
dc.subjectDepressionen_US
dc.subjectHigh-density lipoproteinen_US
dc.subjectHDLen_US
dc.subjectMonocyteen_US
dc.subjectMonocyte to HDL ratioen_US
dc.titleEffects of Major Depressive Disorder on monocytes, High-Density Lipoprotein (LDL) and monocyte to HDL ratio: A case-control studyen_US
dc.titleEffects of Major Depressive Disorder on monocytes, High-Density Lipoprotein (LDL) and monocyte to HDL ratio: A case-control study
dc.typeArticleen_US

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