The uprisal of a lost endemic edible species, Micromeria cymuligera: Comprehensive elucidation of its biological activities and phytochemical composition

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dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-8006-2054en_US
dc.authorid0000-0001-6548-7823en_US
dc.authorid0000-0003-0788-4999en_US
dc.authorid0000-0001-8334-7816en_US
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorÇakır, Oğuz
dc.contributor.authorZengin, Gökhan
dc.contributor.authorİzol, Ebubekir
dc.contributor.authorBehçet, Lütfi̇
dc.date.accessioned2024-08-15T08:51:01Z
dc.date.available2024-08-15T08:51:01Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractBioactive plant species are gaining scientific importance daily. New natural goods with added value are encouraged by the link between health, modern and traditional lifestyles. For about 145 years, Micromeria cymuligera, a Turkish endemic, was presumed extinct. For years, no specimen of this medicinal and fragrant species has been found in the region, but rich populations have lately been found in Bingöl province, Turkey. Like other Micromeria species, M. cymuligera has been used in tea and cooking due to its powerful bioactivities and scent. This is the first study to look at the complete quantification of bioactive phytochemicals, antioxidant capacity, and enzyme inhibitory evaluation of the long-thought-to-be-extinct M. cymuligera species. Using a previously established and validated LC-MS/MS methodology, this study aimed to screen the bioactive phytochemicals of M. cymuligera and assess its diverse antioxidant and enzyme inhibitory properties. The EtOH extract of the species had substantial concentrations of rosmarinic acid (13.05 mg/g extract), quinic acid (4.57 mg/g extract), chlorogenic acid (2.34 mg/g extract), and cynaroside (2.37 mg/g extract), according to LC-MS/MS data. Furthermore, it was shown that the species had relatively high total phenolic-flavonoid contents (40.94 ± 0.38 mgGAEs/g extract and 5.13 ± 0.29 mgREs/g extract, respectively). The extract shown noteworthy activity (82.00 ± 0.74, 126.23 ± 3.43, 48.33 ± 1.36, and 35.89 ± 0.44 mgTEs/g extract in FRAP, CUPRAC, ABTS, and DPPH respectively) in all antioxidant assays when the bioactivity experiments on M. cymuligera were considered. Furthermore, of all the enzyme inhibitory tests (tyrosinase, α-amylase, α-glucosidase, BChE, and AChE), the species demonstrated outstanding inhibitory action against tyrosinase (70.80 ± 1.34 mgKAE/g extract).en_US
dc.identifier.citationYılmaz, M. A., Çakır, O., Zengin, G., İzol, E. ve Behçet, L. (2024). The uprisal of a lost endemic edible species, Micromeria cymuligera: Comprehensive elucidation of its biological activities and phytochemical composition. Food Bioscience, 61, 1-10.en_US
dc.identifier.endpage10en_US
dc.identifier.issn2212-4292
dc.identifier.scopus2-s2.0-85197597189
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2212429224011209?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/28740
dc.identifier.volume61en_US
dc.identifier.wosWOS:001267597100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorÇakır, Oğuz
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofFood Bioscience
dc.relation.isversionof10.1016/j.fbio.2024.104690en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant activityen_US
dc.subjectEnzyme inhibitory activityen_US
dc.subjectLC-MS/MSen_US
dc.subjectLost speciesen_US
dc.subjectMicromeria cymuligeraen_US
dc.titleThe uprisal of a lost endemic edible species, Micromeria cymuligera: Comprehensive elucidation of its biological activities and phytochemical compositionen_US
dc.titleThe uprisal of a lost endemic edible species, Micromeria cymuligera: Comprehensive elucidation of its biological activities and phytochemical composition
dc.typeArticleen_US

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