Therapeutic potential of Hyoscyamus niger-derived compounds: Targeting ovarian cancer through antioxidant activity and EGFR tyrosine kinase inhibition

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dc.authorid0000-0002-7946-219Xen_US
dc.authorid0000-0003-2866-635Xen_US
dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0003-4467-5387en_US
dc.contributor.authorLekmine, Sabrina
dc.contributor.authorBenslama, Ouided
dc.contributor.authorKadi, Kenza
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorAli, Ahmad
dc.contributor.authorOla, Mohammad Shamsul
dc.contributor.authorGarcía, Antonio Ignacio Martín
dc.date.accessioned2024-04-17T08:16:55Z
dc.date.available2024-04-17T08:16:55Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractOvarian cancer poses a significant challenge to women's health, necessitating innovative therapeutic approaches. This study investigates the therapeutic potential of compounds derived from Hyoscyamus niger, a medicinal plant with a history of traditional use, focusing on their antioxidant properties and their ability to inhibit epidermal growth factor-receptor (EGFR) tyrosine kinase a promising target in cancer therapy. LC-ESI-MS/MS analysis of H. niger extract revealed the presence of 21 phenolic compounds, with luteolin and p-coumaric acid notably exhibiting the highest concentrations. The extract displayed robust antioxidant activity across multiple assays, and its performance in the Reducing Power assay highlights its potential in reducing oxidative stress. Molecular docking results indicate that several phenolic compounds may serve as EGFR inhibitors, offering promising avenues for further investigation in cancer therapy. Notably, hyperoside emerged as a strong candidate due to its favorable binding energy and interactions within the EGFR active site. This study demonstrates the therapeutic promise of H. niger-derived compounds in targeting ovarian cancer through antioxidant activity and EGFR inhibition. Further research is warranted to validate their efficacy and safety, potentially opening up new avenues for ovarian cancer treatment.en_US
dc.identifier.citationLekmine, S., Benslama, O., Kadi, K., García, A. I. M., Ola, M. S., Yılmaz, M. A. ve diğerleri. (2024). Therapeutic potential of Hyoscyamus niger-derived compounds: Targeting ovarian cancer through antioxidant activity and EGFR tyrosine kinase inhibition. Journal of King Saud University - Science, 36(3), 1-7.en_US
dc.identifier.doi10.1016/j.jksus.2024.103103
dc.identifier.endpage7en_US
dc.identifier.issn1018-3647
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85185158924
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1018364724000156?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13898
dc.identifier.volume36en_US
dc.identifier.wosWOS:001172920600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of King Saud University - Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant activityen_US
dc.subjectHyoscyamus nigeren_US
dc.subjectLC-MS/MSen_US
dc.subjectOvarian canceren_US
dc.titleTherapeutic potential of Hyoscyamus niger-derived compounds: Targeting ovarian cancer through antioxidant activity and EGFR tyrosine kinase inhibitionen_US
dc.titleTherapeutic potential of Hyoscyamus niger-derived compounds: Targeting ovarian cancer through antioxidant activity and EGFR tyrosine kinase inhibition
dc.typeArticleen_US

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