Effects of Nicotine on Rat Tongue Muc Histopathological and Immunohistochemical Analysis

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dc.contributor.authorEratilla, Veysel
dc.contributor.authorUysal, Ibrahim
dc.contributor.authorDeveci, Engin
dc.contributor.authorGunes, Rojdan Ferman
dc.contributor.authorEratilla, Elif
dc.contributor.authorYildiz, Ismail
dc.contributor.authorSoker, Sevda
dc.date.accessioned2024-04-24T17:44:55Z
dc.date.available2024-04-24T17:44:55Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate the histopathological and immunohistochemical effects of systemically administered nicotine on rat tongue mucosa. STUDY DESIGN: Rats were assigned to groups: the experimental group received nicotine ically (nicotine sulphate 2 mg/kg subcutaneously for 28 days), while the rats in the trol grow ere administered physiological saline mL subcutaneously for 28 days). All animals sacrificed at the end of the study, and tongue tissue ere removed and prepared according his histological procedures. Sections were sta toxylin a sin and observed by. Immunorec y of tongue mucosa , 'E-ca Ilagen IV, and VEr by immunhistochemical staining. RESULTS: There w if cant differences in the average histlogical a between the nicotine-treated treated gr Morphological changes, including inflammatory I to infiltration and cellular desquamation, blood dilation, hemorrhage, and epithelial degeneration r. re noted. Further, E-cadherin expression w significantly decreased in the nicotine-treated grow,w the untreated group. The nicotine treat up showed an increase in collagen IV secondary ae and basal cells. CONCLUSION: The increased level of VEGF exprescs n in the nicotine-treated group may have affected endothelial cell apoptosis.en_US
dc.identifier.endpage22en_US
dc.identifier.issn0884-6812
dc.identifier.issue1en_US
dc.identifier.pmid27363062
dc.identifier.startpage17en_US
dc.identifier.urihttps://hdl.handle.net/11468/22347
dc.identifier.volume38en_US
dc.identifier.wosWOS:000381062100003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCollagen Type Iven_US
dc.subjectE-Cadherinen_US
dc.subjectNicotineen_US
dc.subjectTongueen_US
dc.subjectType Iv Collagenen_US
dc.subjectVegfen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.titleEffects of Nicotine on Rat Tongue Muc Histopathological and Immunohistochemical Analysisen_US
dc.titleEffects of Nicotine on Rat Tongue Muc Histopathological and Immunohistochemical Analysis
dc.typeArticleen_US

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