The accumulation and histological effects of organometallic fungicides propineb and maneb in the livers of pregnant rats and their offspring

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dc.contributor.authorDeveci, Engin
dc.contributor.authorGüven, Kemal
dc.contributor.authorBaşhan, Mehmet
dc.contributor.authorÖnen, Abdurrahman
dc.contributor.authorDe Pomerai, David
dc.date.accessioned2024-04-24T17:56:52Z
dc.date.available2024-04-24T17:56:52Z
dc.date.issued1999
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractDithiocarbamate propineb and maneb are organometal fungicides, which are widely used for the control of diseases in plants. Female Wistar rats were exposed orally to 200 and 400 ppm propineb (Zn-containing dithiocarbamate) and 250 ppm maneb (Mn-containing dithiocarbamate), from the 6th day of gestation up to birth. We found that the body weights of both newborn litters and their fungicide-treated mothers were lower than those of controls. Histological examination of the livers of fungicide-treated pregnant females and the offspring showed a variety of histopathological effects. Moreover, the analysis of Zn and Mn concentrations in the livers of pregnant females exposed to organometallic fungicides during pregnancy demonstrated that the metal concentrations in the liver were higher than those of controls. Similarly, the hepatic metal concentrations were significantly increased in the litters, indicating the transplacental passage of the organometallic fungicides.en_US
dc.identifier.citationDeveci, E., Güven, K., Başhan, M., Önen, A. ve De Pomerai, D. (1999). The accumulation and histological effects of organometallic fungicides propineb and maneb in the livers of pregnant rats and their offspring. Journal of Toxicological Sciences, 24(2), 79-85.
dc.identifier.doi10.2131/jts.24.79
dc.identifier.endpage85en_US
dc.identifier.issn0388-1350
dc.identifier.issue2en_US
dc.identifier.pmid10349609
dc.identifier.scopus2-s2.0-0032974734
dc.identifier.scopusqualityQ3
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.2131/jts.24.79
dc.identifier.urihttps://hdl.handle.net/11468/23694
dc.identifier.volume24en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherJapanese Society of Toxicologyen_US
dc.relation.ispartofJournal of Toxicological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFungicideen_US
dc.subjectHistopathological effectsen_US
dc.subjectManeben_US
dc.subjectMaternal-fetal metal accumulationen_US
dc.subjectPropineben_US
dc.titleThe accumulation and histological effects of organometallic fungicides propineb and maneb in the livers of pregnant rats and their offspringen_US
dc.titleThe accumulation and histological effects of organometallic fungicides propineb and maneb in the livers of pregnant rats and their offspring
dc.typeArticleen_US

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