Effects of Melatonin on Tibia Bone Defects in Rats

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dc.contributor.authorKoparal, M.
dc.contributor.authorIrtegun, S.
dc.contributor.authorAlan, H.
dc.contributor.authorDeveci, E.
dc.contributor.authorGulsun, B.
dc.contributor.authorPektanc, G.
dc.date.accessioned2024-04-24T17:24:11Z
dc.date.available2024-04-24T17:24:11Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effects of melatonin healing in a tibial bone defect model in rats by means of histopathological and immunohistochemistry analysis. Twenty one male Wistar albino rats were used in this study. In each animal, bone defects (6 mm length) were created in the tibias. The animals were divided into three groups. In group 1 control group (rats which tibial defects). Group 2 melatonin (10 mg/kg) + 14 days in the tibial defect group) was administered intraperitoneally to rats. Group 3 melatonin (10 mg/kg) + 28 days in the tibial defect group) was administered intraperitoneally to rats. Histopathological analysis of samples was performed to evaluate the process of osteoblastic activity, matrix formation, trabecular bone formation and myeloid tissue in bone defects. Immunohistochemical and immunoblot analysis demonstrated non-collagenous proteins (osteopontin and osteonectin) differences in tibial bone defects. The expression of osteopontin on tibia was increased by 14 days melatonin treatment. The expression of osteonectin on tibia was dramatically increased by 14 days melatonin treatment.en_US
dc.identifier.doi10.4067/S0717-95022016000200053
dc.identifier.endpage769en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84978394276
dc.identifier.scopusqualityQ3
dc.identifier.startpage763en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022016000200053
dc.identifier.urihttps://hdl.handle.net/11468/19492
dc.identifier.volume34en_US
dc.identifier.wosWOS:000379751100053
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTibial Defectsen_US
dc.subjectMelatoninen_US
dc.subjectOsteonectinen_US
dc.subjectOsteopontinen_US
dc.titleEffects of Melatonin on Tibia Bone Defects in Ratsen_US
dc.titleEffects of Melatonin on Tibia Bone Defects in Rats
dc.typeArticleen_US

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