Antioxidant activities of ethanol extracts of Hypericum triquetrifolium and Hypericum scabroides

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dc.contributor.authorKizil, Goeksel
dc.contributor.authorKizil, Murat
dc.contributor.authorYavuz, Murat
dc.contributor.authorEmen, Sevil
dc.contributor.authorHakimoglu, Fidan
dc.date.accessioned2024-04-24T17:07:46Z
dc.date.available2024-04-24T17:07:46Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe antioxidative potential of ethanol extracts of Hypericum triquetrifolium Turra (Hypericaceae) and Hypericum scabroides Robson Poulter (Hypericaceae) were investigated for the first time using 1,1-diphenyl-2-picrylhydrazyl (DPPH), metal chelating, reducing power, hydroxyl radical, total antioxidant activity, and lipid peroxidation inhibition assays. Both extracts tested were found to be highly active in the DPPH radical scavenging assay. The IC50 values of H. triquetrifolium (HT) and H. scabroides (HS) in the DPPH radical scavenging assay were 39.0 and 33.8 mu g/mL, respectively. The amounts of total phenolic compounds were also determined, and total phenolic content of 1 mg H. triquetrifolium and H. scabroides ethanol extracts were equivalent to 267 and 333 mu g gallic acid. Metal chelating ability was found to be low compared with EDTA. Both ethanol extracts of Hypericum species exhibited a high reducing power, suggesting that extracts had strong electron-donating capacity. The degradation of deoxyribose by hydroxyl radicals was shown to be inhibited by Hypericum extracts, acting mainly by scavenging hydroxyl radicals rather than as chelators of iron ions. Total antioxidant activity of ethanol extracts of HT and HS were tested by using ferric thiocyanate (FTC) and thiobarbituric acid (TBA) methods. Antioxidative activities of both extracts were found to be comparable with vitamin E. Moreover, both extracts showed notable capacity to suppress Fe2+-induced lipid peroxidation in rat brain homogenate. The results obtained in the current study indicate that ethanol extracts of HS and HT are a potential source of natural antioxidants.en_US
dc.identifier.doi10.1080/13880200701739363
dc.identifier.endpage242en_US
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-41449083680
dc.identifier.scopusqualityQ1
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.1080/13880200701739363
dc.identifier.urihttps://hdl.handle.net/11468/16973
dc.identifier.volume46en_US
dc.identifier.wosWOS:000254395500002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPharmaceutical Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant Activityen_US
dc.subjectFree Radical Scavengingen_US
dc.subjectHypericum Scabroidesen_US
dc.subjectHypericum Triquetrifoliumen_US
dc.subjectLipid Peroxidationen_US
dc.titleAntioxidant activities of ethanol extracts of Hypericum triquetrifolium and Hypericum scabroidesen_US
dc.titleAntioxidant activities of ethanol extracts of Hypericum triquetrifolium and Hypericum scabroides
dc.typeArticleen_US

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