The Role of CA-125 in Differential Diagnosis of Ascites

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dc.contributor.authorTuzun, Yekta
dc.contributor.authorBayan, Kadim
dc.contributor.authorAltintas, Abdullah
dc.contributor.authorCil, Timucin
dc.contributor.authorErdemoglu, Mahmut
dc.contributor.authorYilmaz, Serif
dc.contributor.authorDursun, Mehmet
dc.date.accessioned2024-04-24T17:27:35Z
dc.date.available2024-04-24T17:27:35Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: CA-125 has been found to be high in almost all the patients with ascites. In this study, we tried to determine cut-off values of CA-125 in serum and ascitic fluid levels in order to discriminate non-ovarian malignancies, ovarian carcinomas and benign diseases. Material and Methods: A total of 119 patients were included in the study. The patients were divided into three groups: non-ovarian malignancies, ovarian carcinoma and benign diseases. Serum and ascitic fluid CA-125 levels were measured by electrochemiluminescence immunoassay, 'ECLIA' method. In determining the discriminitive ability of CA-125 levels between the groups, receiver operating characteristic (ROC) analysis was performed. Results: A total of 119 patients were included in the study: 55 males and 64 females. Of patients, 53 had non-ovarian malignancy, 19 had ovarian carcinoma and 47 had benign diseases. Serum and ascitic fluid CA-125 levels were high in all of the three groups. When cut-off value of ascitic CA-125 was taken as 174 U/mL, the sensitivity and specificity were found to be 69.2% and 25.5%, respectively; however, when the value was accepted as 796.5 U/mL, these rates were observed as 30.8% and 80.9% respectively. In the discrimination between ovarian carcinoma and benign diseases, when the cut-off value of ascitic CA-125 was considered as 411 U/mL, the sensitivity and specificity were obtained as 94.7% and 63.8% respectively. When the value was taken as 971.9 U/mL, the sensitivity and specificity rates were 57.9% and 78.7% respectively. Conclusion: In discriminating between malign and benign ascites, ascitic CA-125 levels rather than serum values are of significance, and it can be suggested that malignancy should be persistently searched when the value is over 1000 U/mL.en_US
dc.identifier.doi10.5336/medsci.2008-9197
dc.identifier.endpage615en_US
dc.identifier.issn1300-0292
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-77952934665
dc.identifier.scopusqualityQ4
dc.identifier.startpage610en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2008-9197
dc.identifier.urihttps://hdl.handle.net/11468/20072
dc.identifier.volume30en_US
dc.identifier.wosWOS:000277987300024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCa-125 Antigenen_US
dc.subjectAscitesen_US
dc.titleThe Role of CA-125 in Differential Diagnosis of Ascitesen_US
dc.titleThe Role of CA-125 in Differential Diagnosis of Ascites
dc.typeArticleen_US

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