Matairesinol induced antiproliferative effects via mitochondrial dysfunction in HepG2 cells

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dc.contributor.authorArzuk, Ege
dc.contributor.authorErguc, Ali
dc.contributor.authorDemir, Serhat
dc.contributor.authorUnver Somer, Nehir
dc.contributor.authorTan, Iclal
dc.contributor.authorAtis, Ecrin
dc.date.accessioned2025-02-22T14:08:43Z
dc.date.available2025-02-22T14:08:43Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractHepatocellular carcinoma is one of the most severe and life-threatening types of cancer. The conventional treatment of hepatoma has significant challenges due to the adverse effects of chemotherapy, leading to treatment failure and decreased survival. Therefore, developing and investigating novel and safer anticancer drugs and establishing more effective therapeutic regimens is a crucial field of research. The Haplophyllum megalanthum-derived compound matairesinol has demonstrated antiproliferative and antitumor activity against various types of cancer, including pancreatic, breast, and prostate cancer. However, the potential effects of matairesinol on liver cancer, as well as the underlying molecular mechanisms associated with its anticancer activity, have yet to be thoroughly elucidated. In the current study, we demonstrated that matairesinol inhibited the viability of human hepatoma cells in a dose-dependent manner. Besides, at IC50 and higher doses, matairesinol induced oxidative stress and impaired mitochondrial membrane potential and ATP levels, two evidence of mitochondrial damage. Moreover, matairesinol exposure led to significant caspase-3 activation, a hallmark of apoptosis. These results indicate that mitochondrial damage and caspase-3 activation may contribute to the cytotoxic effect of matairesinol on liver cancer cells.en_US
dc.identifier.doi10.29228/jrp.874
dc.identifier.endpage2007en_US
dc.identifier.issn2630-6344
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85213019440en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2001en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.874
dc.identifier.urihttps://hdl.handle.net/11468/29592
dc.identifier.volume28en_US
dc.identifier.wosWOS:001407427700015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherMarmara Univ, Fac Pharmacyen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectMatairesinolen_US
dc.subjectliver canceren_US
dc.subjectmitochondriaen_US
dc.subjectcaspase-3en_US
dc.subjectanticancer effecten_US
dc.titleMatairesinol induced antiproliferative effects via mitochondrial dysfunction in HepG2 cellsen_US
dc.typeArticleen_US

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