CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND PARAOXONASE-1 192 AND 55 GENE POLYMORPHISMS

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dc.contributor.authorTekes, S.
dc.contributor.authorIsik, B.
dc.contributor.authorYildiz, T.
dc.contributor.authorSimsek, S.
dc.contributor.authorIsik, M. R.
dc.contributor.authorBudak, T.
dc.date.accessioned2024-04-24T17:20:21Z
dc.date.available2024-04-24T17:20:21Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractChronic obstructive pulmonary disease (COPD) is a leading cause of chronic morbidity and mortality. The oxidative stress is increased in COPD patients. Paraoxonase (PON1) in the lung may have a role to protect from oxidative stress. We have investigated a possible relationship between PON1 55 and PON1 192 gene polymorphisms in COPD patients and control subjects. A Total of 62 inpatients of COPD, 45 non-smokers and 35 smokers without COPD were included in the study The serum levels of PON1 were measured. The PON1 genotypes were determined by PCR amplification of the region containing the polymorphism followed by restriction enzyme digestion. The serum levels of PON1 were significantly low in the COPD patients group (p<0.001). There were no statistical differences between the COPD and control groups for PON1 55 polymorphism. The PON1 192 QQ and QR genotypes occurred with similar frequencies in the COPD and control groups with no significant differences while a significant difference was found between the PON1 192 RR allele frequencies (p<0.05) of all groups. PON1 192 gene polymorphism may be considered associated with COPD. PON1 polymorphisms and low PON1 activity levels might be considered as an independent risk factor for COPD.en_US
dc.identifier.doi10.2478/V10133-010-0019-1
dc.identifier.endpage1647en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-77950121932
dc.identifier.scopusqualityQ3
dc.identifier.startpage1644en_US
dc.identifier.urihttps://doi.org/10.2478/V10133-010-0019-1
dc.identifier.urihttps://hdl.handle.net/11468/18963
dc.identifier.volume24en_US
dc.identifier.wosWOS:000276230500019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopden_US
dc.subjectPon1en_US
dc.subjectPon1 192 Gene Polymorphismen_US
dc.subjectPon1 55 Gene Polymorphismen_US
dc.subjectSpirometryen_US
dc.titleCHRONIC OBSTRUCTIVE PULMONARY DISEASE AND PARAOXONASE-1 192 AND 55 GENE POLYMORPHISMSen_US
dc.titleCHRONIC OBSTRUCTIVE PULMONARY DISEASE AND PARAOXONASE-1 192 AND 55 GENE POLYMORPHISMS
dc.typeArticleen_US

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