Synthesis and characterization of a polydioxanone-coated dipeptide-functionalized magnetic ?-Fe2O3 nanoparticles-modified PES membrane and its biological applications

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dc.authorid0000-0001-9511-2010en_US
dc.authorid0000-0002-8544-1184en_US
dc.authorid0000-0003-0172-6957en_US
dc.authorid0000-0001-7384-7358en_US
dc.authorid0000-0002-7805-9315en_US
dc.authorid0000-0001-5223-9919en_US
dc.contributor.authorDemirci, Özlem
dc.contributor.authorGonca, Serpil
dc.contributor.authorTolan, Veysel
dc.contributor.authorÖzdemir, Sadin
dc.contributor.authorDizge, Nadir
dc.contributor.authorKılınç, Ersin
dc.date.accessioned2024-01-09T05:50:02Z
dc.date.available2024-01-09T05:50:02Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThis work is focused on the synthesis of leucyl-glycine-functionalized γ-Fe2O3 magnetic nanoparticles coated by polydioxanone (γ-Fe2O3-CA-Leu-Gly-PDX) as a polyethersulphone (PES) membrane for biotechnological applications. The physicochemical characteristics were investigated by FT-IR, SEM, XRD, a vibrating sample magnetometer (VSM), and ICP-OES. The present investigation also centered on the several biological activities of γ-Fe2O3-CA-Leu-Gly-PDX. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and metal chelating activity was studied for evaluation of its antioxidant activity potential. It exhibited 100% DPPH radical scavenging and 93.33% metal chelating activity. With applicability to antimicrobial photodynamic therapy, DNA cleavage and antimicrobial activity, the cell viability of γ-Fe2O3-CA-Leu-Gly-PDX was investigated in detail. The γ-Fe2O3-CA-Leu-Gly-PDX demonstrated the significant biofilm inhibition activity as being 81.54% and 86.34% for P. aeruginosa and S. aureus, respectively. Moreover, a novel polyethersulphone nanocomposite membrane incorporated with γ-Fe2O3-CA-Leu-Gly-PDX was prepared. The performance of the γ-Fe2O3-CA-Leu-Gly-PDX-blended polyethersulphone (PES) membrane was investigated by measuring the antifouling and E. coli rejection. The nanocomposite membranes demonstrated remarkable antifouling properties in contrast with the pristine PES when BSA (bovine serum albumin) and E. coli were filtrated. A complete rejection was obtained by the composite membrane. After an application of the membrane study, the modified polyethersulphone (PES) membrane blended with γ-Fe2O3-CA-Leu-Gly-PDX removed 100% of the E. coli.en_US
dc.identifier.citationDemirci, Ö., Gonca, S., Tolan, V., Özdemir, S., Dizge, N. ve Kılınç, E. (2022). Synthesis and characterization of a polydioxanone-coated dipeptide-functionalized magnetic γ-Fe2O3 nanoparticles-modified PES membrane and its biological applications. Catalysts, 12(10), 1-18.en_US
dc.identifier.doi10.3390/catal12101261
dc.identifier.endpage18en_US
dc.identifier.issn2073-4344
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85140911295
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.mdpi.com/2073-4344/12/10/1261
dc.identifier.urihttps://hdl.handle.net/11468/13154
dc.identifier.volume12en_US
dc.identifier.wosWOS:000872647000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDemirci, Özlem
dc.institutionauthorTolan, Veysel
dc.institutionauthorKılınç, Ersin
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofCatalysts
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiotechnologyen_US
dc.subjectE. colien_US
dc.subjectMagnetic nanomaterialsen_US
dc.subjectNanocomposite PES membraneen_US
dc.subjectProtein separationen_US
dc.titleSynthesis and characterization of a polydioxanone-coated dipeptide-functionalized magnetic ?-Fe2O3 nanoparticles-modified PES membrane and its biological applicationsen_US
dc.titleSynthesis and characterization of a polydioxanone-coated dipeptide-functionalized magnetic ?-Fe2O3 nanoparticles-modified PES membrane and its biological applications
dc.typeArticleen_US

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