Chromosome heteromorphisms are more frequent in couples with recurrent abortions

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dc.contributor.authorAkbas, H.
dc.contributor.authorIsi, H.
dc.contributor.authorOral, D.
dc.contributor.authorTurkyilmaz, A.
dc.contributor.authorKalkanli-Tas, S.
dc.contributor.authorSimsek, S.
dc.contributor.authorBalkan, M.
dc.date.accessioned2024-04-24T17:24:21Z
dc.date.available2024-04-24T17:24:21Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractChromosomal heteromorphism is considered a variant of a normal karyotype, but it is more frequent in couples with repeated miscarriages. We investigated chromosomal heteromorphism in couples with repeated miscarriages in comparison with a control group. A total of 455 couples who applied to our genetic diagnosis laboratory in Diyarbakir, Turkey, were evaluated for chromosome heteromorphisms; 221 of these couples (the study group) had recurrent abortions and 234 of them (the control group) had no history of abortions and had at least one living child. The patient group of couples with recurrent abortions were found to have a significantly higher rate of chromosome heteromorphism (8.4%) in comparison with the control group (4.9%). When the patients were evaluated according to gender, males had a significantly higher rate of chromosome heteromorphism (11.3%) than females (5.4%). We conclude that since couples with recurrent abortion and males have higher rate of chromosome heteromorphism, cases of heteromorphism should not be disregarded in the etiological investigation of recurrent abortions. Further research should be done to investigate the phenotypic effects of chromosome heteromorphism.en_US
dc.identifier.doi10.4238/2012.November.12.1
dc.identifier.endpage3851en_US
dc.identifier.issn1676-5680
dc.identifier.issue4en_US
dc.identifier.pmid23212323
dc.identifier.startpage3847en_US
dc.identifier.urihttps://doi.org/10.4238/2012.November.12.1
dc.identifier.urihttps://hdl.handle.net/11468/19631
dc.identifier.volume11en_US
dc.identifier.wosWOS:000313960500030
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherFunpec-Editoraen_US
dc.relation.ispartofGenetics and Molecular Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytogeneticen_US
dc.subjectChromosome Heteromorphismen_US
dc.subjectRecurrent Pregnancy Lossen_US
dc.titleChromosome heteromorphisms are more frequent in couples with recurrent abortionsen_US
dc.titleChromosome heteromorphisms are more frequent in couples with recurrent abortions
dc.typeArticleen_US

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