Fluid resuscitation in the treatment of uncontrolled hemorrhagic shock

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dc.contributor.authorYagmur, Y.
dc.contributor.authorOzturk, H.
dc.contributor.authorOrak, M.
dc.contributor.authorTas, A.
dc.contributor.authorGuneli, E.
dc.date.accessioned2024-04-24T16:02:04Z
dc.date.available2024-04-24T16:02:04Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: We evaluated the effect of continuous fluid resuscitation on the hemodynamic response and survival following massive splenic injury (MSI) in rats. Methods: Uncontrolled hemorrhagic shock was produced in 70 rats by sharp transaction. The animals were randomized into 7 groups: group 1 (n = 10), sham-operated; group 2 (n = 10), MSI was untreated and splenectomy was performed after 45 min; group 3 (n = 10), MSI treated after 15 min with 7.5 ml/kg/h of 7.5% NaCl (HTS-7.5) and splenectomy after 45 min; group 4 (n = 10), MSI treated with 35 mL/kg/h Ringers lactate (RL) solution (RL-35) and splenectomy; group 5 (n = 10), MSI treated with 70 mL/kg/h RL (RL-70) and splenectomy, group 6 (n=10), NISI treated with 35mL/kg/h of 0.9% NaCl (NaCl-35) and splenectomy; and group 7 (n=10), MSI treated with 70mL/kg/h of 0.9% NaCl (NaCl-70) and splenectomy. Results: Small and high volume ringer lactate (RL-35, RL-70) infusion increased MAP, pulse rate, and hematocrit level compared to untreated group (p<0.001); however, best response was inquired by RL-35. TBL with RL-35 (22% of blood volume) was less than RL-70 and other groups (p<0.01). High rate of early mortality (33.4% at 30min) with HTS infusion was noticed. TBL was moderately increased in NaCl-70 (32% of blood volume) compared to NaCl-35 (30% of blood volume). Survival time was better with RL-35 and RL-70 at 60 min and 120min, respectively, compared to other groups (p < 0.05). Conclusions: In conclusion, continuous infusion of HTS, RL-70, NaCl-35 and NaCl-70 following massive splenic injury in uncontrolled hemorrhagic shock resulted in a significant increase in intra-abdominal bleeding compared to lower dose RL-35 and greatest survival time was noticed with RL-35 and RL-70 at 60 and 120 min, respectively.en_US
dc.identifier.doi10.1007/s10353-008-0409-x
dc.identifier.endpage134en_US
dc.identifier.issn1682-8631
dc.identifier.issn1682-4016
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-46749127476
dc.identifier.scopusqualityQ3
dc.identifier.startpage130en_US
dc.identifier.urihttps://doi.org/10.1007/s10353-008-0409-x
dc.identifier.urihttps://hdl.handle.net/11468/14613
dc.identifier.volume40en_US
dc.identifier.wosWOS:000257755400009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofEuropean Surgery-Acta Chirurgica Austriaca
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUncontrolled Hemorrhagic Shocken_US
dc.subjectMassive Splenic Injury In Ratsen_US
dc.titleFluid resuscitation in the treatment of uncontrolled hemorrhagic shocken_US
dc.titleFluid resuscitation in the treatment of uncontrolled hemorrhagic shock
dc.typeArticleen_US

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