Experimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulp

Basit Öğe Kaydı
dc.contributor.authorUysal, Ibrahim
dc.contributor.authorGokalp-Ozkorkmaz, Ebru
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:24:11Z
dc.date.available2024-04-24T17:24:11Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of this study was to examine the expression levels of the dental pulp to elucidate the role of Vascular Endothelial Growth Factor (VEGF) and CD68 on vascular angiogenesis, inflammation and odontoblast differentiation in the pulp tissue of diabetic rats depending on the effect of possible damage induced by diabetes. Wistar rats were used in the study, divided into two groups. Control group was fed with standard rat chow and drinking water ad libitum for 8 weeks. Single dose of streptozotocin (STZ) (55 mg/kg), was disolved in sodium citrate buffer and administered by intraperitoneal injection. Blood glucose concentration of rats exceeding 250 mg/dl were accepted as diabetic. Rats were sacrificed under anesthesia. Tissues were immediately dissected, fixed and embedded in paraffin and cut with a microtome then examined under light microscope. In the cross-sections of pulp tissue of diabetic group; the dilation of blood vessels besides hemorrhage and a significant increase in inflammatory cells were seen. The expression of VEGF in the blood vessel endothelial cells of the pulp was increased. VEGF showed positive reaction for degenerative odontoblast cells in the pulp. In this study, increase in VEGF and CD68 expressions in pulp tissue due to the effect of diabetes was thought to delay pulp treatment by inducing soft tissue damage and hypoxia.en_US
dc.identifier.doi10.4067/S0717-95022019000200606
dc.identifier.endpage611en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85067506640
dc.identifier.scopusqualityQ3
dc.identifier.startpage606en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022019000200606
dc.identifier.urihttps://hdl.handle.net/11468/19498
dc.identifier.volume37en_US
dc.identifier.wosWOS:000466984400032
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVegfen_US
dc.subjectCd68en_US
dc.subjectDiabetes Mellitusen_US
dc.subjectTeethen_US
dc.subjectRaten_US
dc.titleExperimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulpen_US
dc.titleExperimentally Induced Diabetes Mellitus Influences Expression of VEGF and CD68 in Rat Teeth Pulp
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu