A comparison of the mixed and sequential use of acetaminophen and dexketoprofen in painful vaso-occlusive crises

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dc.contributor.authorKacmaz, Murat
dc.contributor.authorIlhan, Gul
dc.date.accessioned2024-04-24T15:59:49Z
dc.date.available2024-04-24T15:59:49Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose Opioids are widely used to treat painful vaso-occlusive crises (VOC) in sickle cell disease (SCD). However, due to opioids' significant adverse effect profiles, the search for alternative therapies continues from the past to the present. The study aimed to investigate the efficacy of acetaminophen and dexketoprofen in the treatment of painful VOC.Methods This study is a single-center, prospective, non-randomized, single-blinded, controlled study. The study comprised two groups: the first administered acetaminophen and dexketoprofen mixed group, while the second received them sequential group. Opioids were used in patients with persistent pain despite these analgesics. Demographic and laboratory information, pain scores, opioid requirement, dose amount, side effects, and length of hospital stay of the patients were recorded.Results The study comprised 56 (100%) patients with painful VOC, 29 (51.8%) from the mixed group, and 27 (48.2%) from the sequential group. Opioid use was seen in 16 (55.2%) patients in the mixed group and 21 (77.8%) patients in the sequential group (p = 0.074). The median amount of opioid used was significantly lower in the mixed group than in the sequential group (p < 0.001). Also, the median length of hospital stay was significantly lower in the mixed group than in the sequential group (p < 0.001).Conclusion Our study suggests that administering acetaminophen and dexketoprofen in the mix for the treatment of painful VOC in patients with SCD may be a more efficient approach compared to sequential administration. This approach appears to reduce opioid usage and shorten hospital stays.en_US
dc.identifier.doi10.1007/s00228-024-03630-8
dc.identifier.endpage480en_US
dc.identifier.issn0031-6970
dc.identifier.issn1432-1041
dc.identifier.issue3en_US
dc.identifier.pmid38245872
dc.identifier.startpage475en_US
dc.identifier.urihttps://doi.org/10.1007/s00228-024-03630-8
dc.identifier.urihttps://hdl.handle.net/11468/14271
dc.identifier.volume80en_US
dc.identifier.wosWOS:001145970500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEuropean Journal of Clinical Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemoglobinopathiesen_US
dc.subjectAnemiaen_US
dc.subjectSickle Cellen_US
dc.subjectPainen_US
dc.subjectOpioid-Related Disordersen_US
dc.titleA comparison of the mixed and sequential use of acetaminophen and dexketoprofen in painful vaso-occlusive crisesen_US
dc.titleA comparison of the mixed and sequential use of acetaminophen and dexketoprofen in painful vaso-occlusive crises
dc.typeArticleen_US

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