?-Hydroxyamide derivatives of salicylic acid as organocatalysts for enantioselective reductions of prochiral ketones

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Tarih

2013

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Pergamon-Elsevier Science Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

In order to find the most effective catalyst for the enantioselective reduction of a prochiral ketone, a series of novel beta-hydroxyamide derivatives of salicylic acid and chiral amino alcohols were synthesized. Different substituted prochiral ketones have been reduced in high yield (up to 99%) and the corresponding secondary alcohols are formed with good enantiomeric excess (up to 86%). The mechanism of this type of catalyst can be explained by considering the reaction mechanism for the CBS catalyst. (C) 2013 Elsevier Ltd. All rights reserved.

Açıklama

Anahtar Kelimeler

[No Keyword]

Kaynak

Tetrahedron-Asymmetry

WoS Q Değeri

Q2

Scopus Q Değeri

N/A

Cilt

24

Sayı

13-14

Künye