EFFECT OF FISH-OIL ON INDOMETHACIN-INDUCED GASTRIC-LESIONS IN RATS

The effect of fish oil in promoting the healing of indometacin-induced gastric lesions was investigated in Wistar albino rats, After indometacin treatment (30 mg/kg, s.c.), animals were given fish oil, olive oil, or normal diet for 48 h. Thr ulcer index was found to be decreased to 2.1 +/- 1.8 mm with fish oil 13.7 +/- 5.4 mm with olive oil, and 14.6 +/- 2.4 mm with normal diet. Fish oil showed a potent healing-promoting effect on acute gastric erosions and ulcers induced by indometacin anti significantly, enhanced the mucus content of the mucosa (p < 0.05).