Effects of Pulsed and Sinusoidal Electromagnetic Fields on MMP-2, MMP-9, Collagen Type IV and E-cadherin Expression Levels in the Rat Kidney An Immunohistochemical Study

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dc.contributor.authorTunik, Selcuk
dc.contributor.authorAyaz, Ercan
dc.contributor.authorAkpolat, Veysi
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorIsen, Kenan
dc.contributor.authorCelik, M. Salih
dc.contributor.authorSeker, Ugur
dc.date.accessioned2024-04-24T17:47:27Z
dc.date.available2024-04-24T17:47:27Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the role of extremely low frequency pulsed and sinusoidal electromagnetic fields on kidney tissues. STUDY DESIGN: Twenty-seven male Wistar albino rats were used. The rats were divided into 3 groups (n = 9): control group, sinusoidal electromagnetic field (SEMF) group, and pulsed electromagnetic field (PEMF) group. The SEMF and PEMF groups (pulse time 25 mu sn, pulse frequency 50 Hz) were subjected to 1.5 mT, 50 Hz, exposure 6 hours a day, 5 days a week for 28 days in methacrylate boxes. Formalin-fixed, paraffin-embedded kidney tissue sections were stained with hematoxylin-eosin, Gomori and periodic acid-Schiff. In addition, matrix metalloproteinase-2 (MMP-2) and 9 (MMP-9), E-cadherin and collagen type IV expression levels were examined immunohistochemically. RESULTS: Thickening of glomerular basement membranes was evident in electromagnetic fields, especially in the SEMF group. In addition, expression levels of E-cadherin were decreased with electromagnetic field (EMF) exposure. The expression level of MMP-9 increased, and MMP-2 and collagen type IV expression levels were not altered with EMF exposure. CONCLUSION: Both EMFs changed the molecular component of the kidney adversely.en_US
dc.identifier.endpage260en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.pmid24282905
dc.identifier.startpage253en_US
dc.identifier.urihttps://hdl.handle.net/11468/22487
dc.identifier.volume35en_US
dc.identifier.wosWOS:000326423000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytology and Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCollagen Type Iven_US
dc.subjectE-Cadherinen_US
dc.subjectElectromagnetic Fieldsen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMmp-2 Metalloproteinaseen_US
dc.subjectMmp-9 Metalloproteinaseen_US
dc.titleEffects of Pulsed and Sinusoidal Electromagnetic Fields on MMP-2, MMP-9, Collagen Type IV and E-cadherin Expression Levels in the Rat Kidney An Immunohistochemical Studyen_US
dc.titleEffects of Pulsed and Sinusoidal Electromagnetic Fields on MMP-2, MMP-9, Collagen Type IV and E-cadherin Expression Levels in the Rat Kidney An Immunohistochemical Study
dc.typeArticleen_US

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