Immunohistochemical distributions of leptin, ghrelin and obestatin hormones in bull and ram abomasum

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dc.contributor.authorKarakoç, Zelal
dc.contributor.authorTopaloğlu, Uğur
dc.contributor.authorBayram, Bayram
dc.contributor.orcid0000-0002-0723-4059
dc.contributor.orcid0000-0002-8306-491X
dc.date.accessioned2024-04-24T17:56:28Z
dc.date.available2024-04-24T17:56:28Z
dc.date.issued2022
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Laboratuvar Hayvanları Ana Bilim Dalıen_US
dc.description.abstractIn most mammals, leptin plays central and peripheral roles in a wide range of metabolic activities including feed consumption and digestion, energy expenditure and the regulation of carbohydrate-fat accumulation. Ghrelin is a strong appetite-stimulating hormone, while obestatin has the opposite effect of ghrelin. The latter is released during feeding, causing a sense of satiety. This study aimed to reveal if the metabolic hormones, as well as OB-R and GHS-R, were present in bull and ram abomasums. Streptavidin-biotin peroxidase method was implemented to determine the expressions and localizations of metabolic hormones and their receptors, and obestatin. Immunoreactivity for leptin and obestatin was present in the cytoplasms of luminal and glandular cells, while smooth muscle cells were immunoreactant for ghrelin, in both bull and ram abomasums. Immunoreactivity for OB-R was present in luminal and glandular cell, parietal cell cytoplasms, and blood vessels. Immunoreactivity for GHS-R, on the other hand, was found in glandular epithelial cell cytoplasms and parietal cell cytoplasms, in both bull and ram abomasums. Leptin immunoreactivity was detected in the glandular epithelial cells and stroma, and particularly in the parietal cells. Ghrelin immunoreactivity was not observed in glandular epithelial cells. Obestatin immunoreactivity was found intensely in the bull abomasum, while moderate immunoreactivity was observed in the ram abomasums. As such, leptin, ghrelin and obestatin hormones were expressed in bull and ram abomasums, similar to the abomasums of other species. It is believed that these hormones play important roles in the digestive system activities and the regulation of energy in bulls and rams.en_US
dc.description.sponsorshipWe thank Nurşin Aydın their assistance throughout in laboratory studies of our study.en_US
dc.identifier.citationKarakoç, Z., Topaloğlu, U. ve Bayram, B. (2022). Immunohistochemical distributions of leptin, ghrelin and obestatin hormones in bull and ram abomasum. Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia, 51(3), 411-418.
dc.identifier.doi10.1111/ahe.12801
dc.identifier.endpage418en_US
dc.identifier.issn0340-2096
dc.identifier.issue3en_US
dc.identifier.pmid35288975
dc.identifier.scopus2-s2.0-85126257024
dc.identifier.scopusqualityQ2
dc.identifier.startpage411en_US
dc.identifier.urihttps://doi.org/10.1111/ahe.12801
dc.identifier.urihttps://hdl.handle.net/11468/23528
dc.identifier.volume51en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofJournal of Veterinary Medicine Series C: Anatomia Histologia Embryologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbomasumen_US
dc.subjectBullen_US
dc.subjectMetabolic hormonesen_US
dc.subjectRamen_US
dc.subjectReceptoren_US
dc.titleImmunohistochemical distributions of leptin, ghrelin and obestatin hormones in bull and ram abomasumen_US
dc.titleImmunohistochemical distributions of leptin, ghrelin and obestatin hormones in bull and ram abomasum
dc.typeArticleen_US

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