Synthesis and X-ray crystal structures of three new terpyridine-based Pb(II) complexes, cytotoxicity studies of {[Pb(ttpy)(?-AcO)]2}(SCN)2

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dc.contributor.authorSaghatforoush, Lotfali
dc.contributor.authorSahin, Ertan
dc.contributor.authorBabaei, Somayyeh
dc.contributor.authorBakhtiari, Akbar
dc.contributor.authorNasimian, Ahmad
dc.contributor.authorCelik, Omer
dc.contributor.authorZabihollahi, Zohreh
dc.date.accessioned2024-04-24T16:24:25Z
dc.date.available2024-04-24T16:24:25Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractSynthesis and X-ray crystal structures of three new terpyridine-based Pb(II) complexes, {[Pb(ttpy)(mu-AcO)](2)}(SCN)(2) (1) (ttpy = 4'-tolyl-2,2': 6',2 ''-terpyridine), [Pb(Clphtpy)(AcO)(ClO4)] (2), and [Pb(Clphtpy)(SCN)(2)] (3) (Clphtpy = 4'-(4-chlorophenyl)-2,2': 6',2 ''-terpyridine), are described. The synthesized materials have been characterized, also, by CHN elemental analysis, H-1 NMR, and IR spectroscopy. The structural analyses showed that, in the solid state, the coordination number of Pb(II) in 1, 2, and 3 are six, seven, and five, respectively. In the complexes, the lone-pair electrons of Pb(II) are stereochemically active and the coordination geometry of Pb(II) is hemidirected. The structures of the three complexes were compared and the effect of counter ion is described. The antibacterial activity of 1 and previously reported {[Pb(ttpy)(mu-AcO)](2)}(PF6) 2 (1A) and {[Pb(ttpy)(mu-AcO)I](2)} (1B) were tested by minimum inhibitory concentration method to investigate the effect of counter ions on biological activity of the compounds. Also, cytotoxicity test was assessed using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay to determine the maximum non-toxic concentration of ttpy, Pb(II), and their complexes to HepG2 cells. Effective lead detoxification was observed for 1, 1A, and 1B.en_US
dc.description.sponsorshipPayame Noor University, Iran; Ataturk University, Erzurum, Turkeyen_US
dc.description.sponsorshipSupport of this investigation by the Payame Noor University, Iran and Ataturk University, Erzurum, Turkey is gratefully acknowledged.en_US
dc.identifier.doi10.1080/00958972.2014.909930
dc.identifier.endpage1477en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-84903304393
dc.identifier.scopusqualityQ3
dc.identifier.startpage1463en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2014.909930
dc.identifier.urihttps://hdl.handle.net/11468/16703
dc.identifier.volume67en_US
dc.identifier.wosWOS:000337957500014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLead(Ii) Complexen_US
dc.subjectTerpyridineen_US
dc.subjectX-Ray Crystal Structureen_US
dc.subjectAntibacterial Activityen_US
dc.subjectCytotoxicityen_US
dc.subjectLead Poison Detoxificationen_US
dc.titleSynthesis and X-ray crystal structures of three new terpyridine-based Pb(II) complexes, cytotoxicity studies of {[Pb(ttpy)(?-AcO)]2}(SCN)2en_US
dc.titleSynthesis and X-ray crystal structures of three new terpyridine-based Pb(II) complexes, cytotoxicity studies of {[Pb(ttpy)(?-AcO)]2}(SCN)2
dc.typeArticleen_US

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