Activity, acute and sub-acute toxicity and safety assesment of the hydroalcholic root extract of Diplotaenia turcica

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dc.contributor.authorOzdek, U.
dc.contributor.authorBasbugan, Y.
dc.contributor.authorYildirim, S.
dc.contributor.authorBoga, M.
dc.contributor.authorFirat, M.
dc.contributor.authorDeger, Y.
dc.date.accessioned2024-04-24T17:18:21Z
dc.date.available2024-04-24T17:18:21Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractDiplotaenia turcica is widely utilized in conventional treatment in the east of Turkey. Due to the insufficient data on the safety profile, the acute and sub acute toxicity of Diplotaenia turcica was determined. Furthermore, total phenolic content, flavonoid content and antioxidant activity of the extract were determined. The acute toxicity of hydroalcoholic root extract of Diplotaenia turcica (HREDT) was evaluated in mice after administration of single oral dose at the 5000 mg/kg (acute model) and rat after 28 days orally administration at the dose range of 250, 500 and 1000 mg/kg (subacute model). According to result, the LD50 value of HREDT was found to be greater than 5000 ing/kg. In sub acute toxicity study, no statistically significant differences were observed in the values of hematological and pathological parameters in comparison with control group. It was determined that the glucose, triglyceride, cholesterol and LDL levels exerted a significant effect depending on the HREDT doses. The results from the present study found out that HREDT did not produce any toxic effects or deaths in animals for both single and chronic administration. Additionally, HREDT showed moderate antioxidant activities and exhibited relatively notable total phenolic content.en_US
dc.description.sponsorshipScientific Research Projects Presidency of Yuzuncu Yil University [TSA-2016-5067]en_US
dc.description.sponsorshipWe thank to the Scientific Research Projects Presidency of Yuzuncu Yil University (TSA-2016-5067) for their financial support.en_US
dc.identifier.doi10.18805/ijar.B-901
dc.identifier.endpage1694en_US
dc.identifier.issn0367-6722
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85059685122
dc.identifier.scopusqualityQ3
dc.identifier.startpage1688en_US
dc.identifier.urihttps://doi.org/10.18805/ijar.B-901
dc.identifier.urihttps://hdl.handle.net/11468/18742
dc.identifier.volume52en_US
dc.identifier.wosWOS:000456657300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAgricultural Research Communication Centreen_US
dc.relation.ispartofIndian Journal of Animal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant Capacityen_US
dc.subjectAcute Toxicityen_US
dc.subjectDiplotaenia Turcicaen_US
dc.subjectSub Chronic Toxicityen_US
dc.titleActivity, acute and sub-acute toxicity and safety assesment of the hydroalcholic root extract of Diplotaenia turcicaen_US
dc.titleActivity, acute and sub-acute toxicity and safety assesment of the hydroalcholic root extract of Diplotaenia turcica
dc.typeArticleen_US

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