Relationship between the flow-mediated dilatation of the human brachial artery and blood biomarkers related to the efunction in cardiovascular diseases

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dc.authorid0000-0001-7429-5997en_US
dc.contributor.authorUsanmaz, Suzan Emel
dc.contributor.authorAtar, İnd Aslı
dc.contributor.authorAksoyek, Ayşen
dc.contributor.authorTola, Muharrem
dc.contributor.authorKubatu, Emre
dc.contributor.authorAltuner, Tuğba Kayhan
dc.contributor.authorBozbaş, Hüseyin
dc.contributor.authorSevük, Utkan
dc.contributor.authorKorkmaz, Mehmet Emin
dc.contributor.authorYılmaz, Emine Demirel
dc.date.accessioned2021-04-12T12:56:08Z
dc.date.available2021-04-12T12:56:08Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar CerrahisiAna Bilim Dalıen_US
dc.descriptionWOS:000618207400014
dc.description.abstractObjective: Endothelial dysfunction plays an important role in the development of heart diseases. Although several markers have been examined, a definitive biomarker for monitoring endothelial function has not yet been established. The flow-mediated dilatation (FMD) of the brachial artery enables non-invasive assessment of endothelial function. This study investigated plasma levels of nitric oxide (NO), asymmetric dimethylarginine (ADMA), total antioxidant capacity (TAC), and hydrogen sulfide (H2S) as biomarkers of endothelial function. This study aimed to investigate any correlation between FMD and these blood biomarkers in patients with diabetes mellitus (DM), prediabetes (preDM), coronary artery disease (CAD), and valvular heart disease (VD). Materials and Methods: Prospective evaluation was made within five groups of patients with preDM, DM, CAD, VD, and healthy controls. The FMD of the brachial artery was examined using Doppler imaging, and biomarker levels in plasma were measured by spectrophotometry. Results: The FMD of the VD group was significantly higher than that of DM and CAD groups. Plasma NO levels of CAD and VD groups were significantly lower than those of the control group. ADMA levels were lower in the CAD group. TAC and H2S levels were comparable in all groups. The FMD of the brachial artery was negatively correlated with plasma NO and cholesterol levels in all groups. Conclusion: These results suggested that the correlation of FMD with blood biomarkers related to endothelial function was altered in cardiovascular diseases and would be affected by the patient’s clinical state and treatment.en_US
dc.identifier.citationUsanmaz, S.E., Atar, İ.A., Aksoyek, A., Tola, M., Kubatu, E., Altuner, T.K. ve diğerleri. (2021). Relationship between the flow-mediated dilatation of the human brachial artery and blood biomarkers related to the efunction in cardiovascular diseases. Erciyes Medical Journal, 43(1), 75-82.en_US
dc.identifier.doi10.14744/etd.2020.90592
dc.identifier.endpage82en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue1en_US
dc.identifier.startpage75en_US
dc.identifier.trdizinid486026
dc.identifier.urihttps://jag.journalagent.com/erciyesmedj/pdfs/EMJ_43_1_75_82.pdf
dc.identifier.urihttps://hdl.handle.net/11468/6683
dc.identifier.volume43en_US
dc.identifier.wosWOS:000618207400014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorSevük, Utkan
dc.language.isoenen_US
dc.publisherErciyes University School of Medicineen_US
dc.relation.ispartofErciyes Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFlow-mediated dilatationen_US
dc.subjectEndothelial functionen_US
dc.subjectNitric oxideen_US
dc.subjectADMAen_US
dc.subjectCardiovascular diseasesen_US
dc.titleRelationship between the flow-mediated dilatation of the human brachial artery and blood biomarkers related to the efunction in cardiovascular diseasesen_US
dc.titleRelationship between the flow-mediated dilatation of the human brachial artery and blood biomarkers related to the efunction in cardiovascular diseases
dc.typeArticleen_US

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