Effect of oral pyridoxine hydrochloride supplementation on in vitro platelet sensitivity to different agonists

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dc.contributor.authorSermet A.
dc.contributor.authorAybak M.
dc.contributor.authorUlak G.
dc.contributor.authorGuzel C.
dc.contributor.authorDenli O.
dc.date.accessioned2024-04-24T18:44:06Z
dc.date.available2024-04-24T18:44:06Z
dc.date.issued1995
dc.departmentDicle Üniversitesien_US
dc.description.abstractEffect of vitamin B6 (pyridoxine-HCl, CAS 58-56-0) on platelet aggregation, plasma lipids and serum zinc level was investigated. The trial comprised 24 healthy male volunteers, aged between 19-24 years. The subjects were randomized in two groups of 12 and treated for 4 weeks by a single daily oral dose of 5 mg/kg vitamin B6 or placebo. Pyridoxine inhibited ADP- or epinephrine-induced aggregation by 48% and 41% (p < 0.001), respectively, whereas there was no change in control group. No significant effect on either, bleeding time, coagulation time or on platelet count was demonstrated in subjects given placebo. Pyridoxine prolonged both bleeding and coagulation time but not over the physiological limits. It had no effect on platelet count. These observations strongly suggest that vitamin B6, with no effect on platelet count, not only inhibits platelet aggregation but also prelongs clotting time. Pyridoxine significantly reduced total plasma lipid and cholesterol levels, whereas it enhanced HDL-cholesterol level. Serum zinc level was also significantly increased by pyridoxine (p < 0.001). These findings suggest that oral vitamin B6 inhibits platelet aggregation in normal subjects.en_US
dc.identifier.endpage21en_US
dc.identifier.issn0004-4172
dc.identifier.issue1en_US
dc.identifier.pmid7893263
dc.identifier.scopus2-s2.0-0029122387
dc.identifier.scopusqualityN/A
dc.identifier.startpage19en_US
dc.identifier.urihttps://hdl.handle.net/11468/24559
dc.identifier.volume45en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofArzneimittel-Forschung/Drug Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCas 58-56-0en_US
dc.subjectLipids, İn Plasmaen_US
dc.subjectPyridoxine Hydrochloride, Pharmacology, Platelet Aggregationen_US
dc.subjectVitamin B6en_US
dc.subjectZincen_US
dc.titleEffect of oral pyridoxine hydrochloride supplementation on in vitro platelet sensitivity to different agonistsen_US
dc.titleEffect of oral pyridoxine hydrochloride supplementation on in vitro platelet sensitivity to different agonists
dc.typeArticleen_US

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