Effects on alveolar bone of diabetes mellitus induced by streptozotocin in rats. Histopathologic and immunohistochemical study

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dc.authorid0000-0002-3511-5612en_US
dc.authorid0000-0001-8349-3506en_US
dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorYılmaz, Nezih
dc.contributor.authorUysal, İbrahim
dc.contributor.authorEratilla, Veysel
dc.contributor.authorİrtegün, Sevgi
dc.contributor.authorFerman, Rojda Güneş Uysal
dc.contributor.authorEratilla, Elif
dc.contributor.authorElbey, Hüseyin
dc.contributor.authorUysal, Ersin
dc.contributor.authorDeveci, Buşra
dc.contributor.authorDeveci, Engin
dc.date.accessioned2022-12-12T06:51:14Z
dc.date.available2022-12-12T06:51:14Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Diş Hekimliği Fakültesi, Protetik Diş Tedavisi Bölümüen_US
dc.description.abstractThe purpose of this study was to investigate effects of diabetes mellitus (DM) on the alveolar bone with histopathological and immunohistochemical methods. Wistar rats were divided into two groups, control and diabetes group. Control group was fed standard rat chow and drinking water for 8 weeks. Single dose (Streptozotocin) STZ (55 mg/kg), was dissolved in sodium citrate buffer and introduced intraperitoneal injection. Diabetes group and control group were compared in terms of glucose values. The blood glucose concentration in diabetic rats was significantly high (p <0.05). In diabetes group; periodontal membrane and the dilation of blood vessels, hemorrhage has also been a significant increase in inflammatory cells. In the diabetes group, osteonectin showed positive expression in periodontal membrane and showed negative expression in osteocytes of alveolar bone. Osteopontin expression in fibroblast cells and periodontal membrane collagen fibrils was positive, alveolar cells, osteocytes and bone matrix bone was found positive. Diabetes results showed that there formed periodontitis; due to the increase in inflammation inhibiting bone formation delaying the development of early bone cells.en_US
dc.description.abstractRESUMEN: El objetivo de este estudio fue investigar los efectos de la diabetes mellitus (DM) sobre el hueso alveolar con métodos histopatológicos e inmunohistoquímicos. Las ratas Wistar se dividieron en dos grupos, grupo control y grupo de diabetes. El grupo control fue alimentado con comida estándar y agua potable durante 8 semanas. La dosis única Streptozotocina (STZ) (55 mg/ kg), se disolvió en tampón de citrato de sodio y se introdujo mediante inyección intraperitoneal. El grupo diabetes y el grupo control se compararon en términos de valores de glucosa. La concentración de glucosa en sangre en ratas diabéticas fue significativamente alta (p <0,05). En el grupo diabetes hubo un aumento significativo de la membrana periodontal y dilatación de los vasos sanguíneos y hemorragia, con un aumento significativo de células inflamatorias. En el grupo diabetes, la osteonectina mostró una expresión positiva en la membrana periodontal además se observó expresión negativa en los osteocitos del hueso alveolar. La expresión de osteopontina en fibroblastos y fibrillas de colágeno en membrana periodontal fue positiva, las células alveolares, osteocitos y hueso de la matriz ósea dio positivo. Los resultados de la diabetes mostraron que existía periodontitis, debido al aumento de la inflamación que inhibió la formación ósea retardando el desarrollo de células óseas tempranas.
dc.identifier.citationYılmaz, N., Uysal, İ., Eratilla, V., İrtegün, S., Ferman, R. G. U. ve Eratilla, E. (2018). Effects on alveolar bone of diabetes mellitus induced by streptozotocin in rats. Histopathologic and immunohistochemical study. International Journal of Morphology, 36(1), 206-211.en_US
dc.identifier.doi10.4067/S0717-95022018000100206
dc.identifier.endpage211en_US
dc.identifier.issn0717-9367
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85044584440
dc.identifier.scopusqualityQ3
dc.identifier.startpage206en_US
dc.identifier.urihttps://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100206&lng=en&nrm=iso&tlng=en
dc.identifier.urihttps://hdl.handle.net/11468/11021
dc.identifier.volume36en_US
dc.identifier.wosWOS:000438813400035
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorEratilla, Veysel
dc.institutionauthorİrtegün, Sevgi
dc.institutionauthorEratilla, Elif
dc.institutionauthorElbey, Hüseyin
dc.institutionauthorUysal, Ersin
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlveolar boneen_US
dc.subjectDiabetes mellitusen_US
dc.subjectOsteonectinen_US
dc.subjectOsteopontinen_US
dc.subjectRaten_US
dc.titleEffects on alveolar bone of diabetes mellitus induced by streptozotocin in rats. Histopathologic and immunohistochemical studyen_US
dc.titleEffects on alveolar bone of diabetes mellitus induced by streptozotocin in rats. Histopathologic and immunohistochemical study
dc.typeArticleen_US

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