Design, synthesis and biological evaluation of 1,3-diaryltriazene-substituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors

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dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorAkocak, Süleyman
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorLolak, Nabih
dc.contributor.authorTuneğ, Muhammed
dc.contributor.authorSanku, Rajesh Kishore Kumar
dc.date.accessioned2022-03-02T12:22:53Z
dc.date.available2022-03-02T12:22:53Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstract1,3-diaryltriazenes are one of the most useful and important linkers for many pharmaceutical applications. Therefore, in the current work, a series of 1,3-diaryltriazene sulfonamides 4(a-k) were synthesized by reacting diazonium salt of sulfanilamide and substituted aromatic amine derivatives 3(a-k). The obtained compounds were investigated for antioxidant properties by using different methods such as a DPPH radical scavenging assay, ABTS radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. The cholinesterase inhibition activities (acetylcholinesterase and butyrylcholinesterase) of synthesized compounds were also tested. In general, compounds showed weak antioxidant activity, except compounds 4d (IC50 =114.89 for DPPH activity), 4i (IC50 =25.31 for ABTS activity), 4a (IC50 = 86.33 for metal chelating activity), and 4k (absorbance value 1.229 µM for CUPRAC). Some of the compounds showed great % inhibition against both acetylcholinesterase and butyrylcholinesterase with % inhibition values ranging from 11.54 to 93.67 and 62.24 to 98.47, respectively.en_US
dc.identifier.citationAkocak, S., Boğa, M., Lolak, N., Tuneğ, M. ve Sanku, R. K. K. (2019). Design, synthesis and biological evaluation of 1,3-diaryltriazene-substituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. Journal of the Turkish Chemical Society, Section A: Chemistry, 6(1), 63-70.en_US
dc.identifier.doi10.18596/jotcsa.516444
dc.identifier.endpage70en_US
dc.identifier.issn2149-0120
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85062295189
dc.identifier.scopusqualityQ3
dc.identifier.startpage63en_US
dc.identifier.trdizinid396090
dc.identifier.urihttps://dergipark.org.tr/en/pub/jotcsa/issue/42264/516444
dc.identifier.urihttps://hdl.handle.net/11468/9297
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/396090
dc.identifier.volume6en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBoğa, Mehmet
dc.institutionauthorTuneğ, Muhammed
dc.language.isoenen_US
dc.publisherTurkish Chemical Societyen_US
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subject1;3-diaryltriazeneen_US
dc.subjectSulfanylamideen_US
dc.titleDesign, synthesis and biological evaluation of 1,3-diaryltriazene-substituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitorsen_US
dc.titleDesign, synthesis and biological evaluation of 1,3-diaryltriazene-substituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors
dc.typeArticleen_US

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