Tuberculous meningits in adults in Turkey

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dc.contributor.authorHosoglu, S
dc.contributor.authorGeyik, MF
dc.contributor.authorBalik, I
dc.contributor.authorAygen, B
dc.contributor.authorErol, S
dc.contributor.authorAygencel, SG
dc.contributor.authorMert, A
dc.date.accessioned2024-04-24T17:49:57Z
dc.date.available2024-04-24T17:49:57Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractA retrospective study was performed to assess the epidemiology, diagnosis, clinic, and laboratory of the patients with tuberculous meningitis (TBM) in a multicentral study. The medical records of adult cases with TBM treated at 12 university hospitals throughout Turkey, between 1985 and 1998 were reviewed using a standardized protocol. The diagnosis of TMB was established with the clinical and laboratory findings and/or microbiological confirmation in cerebrospinal fluid (CSF). The non-microbiologically confirmed cases were diagnosed with five diagnostic sub-criteria which CSF findings, radiological findings, extra-neural tuberculosis, epidemiological findings and response to antituberculous therapy. A total of 469 patients were included in this study. Majority of the patients were from Southeast Anatolia (164 patients, 35.0%) and (108 patients, 23.0%) from East Anatolia regions. There was a close contact with a tuberculous patient in 88 of 341 patients (25.8%) and with a tuberculous family member in 53 of 288 patients (18.4%). BCG scar was positive in 161 of 392 patients (41.1%). Tuberculin skin test was done in 233 patients and was found to be negative in 75. Totally 115 patients died (24.5%) of whom 23 died in 24 hour after admittance. The diagnosis was confirmed with clinical findings and CSF culture and/or Ziehl-Nelson staining in 88 patients (18.8%). Besides clinical criteria, there were three or more diagnostic sub-criteria in 252 cases (53.7%), two diagnostic sub-criteria in 99 cases (21.1%), and any diagnostic sub-criteria in 30 patients (6.4%). Since TBM is a very critical disease, early diagnosis and treatment may reduce fatal outcome and morbidity.en_US
dc.identifier.endpage343en_US
dc.identifier.issn0393-2990
dc.identifier.issn1573-7284
dc.identifier.issue4en_US
dc.identifier.pmid12803374
dc.identifier.startpage337en_US
dc.identifier.urihttps://hdl.handle.net/11468/23116
dc.identifier.volume18en_US
dc.identifier.wosWOS:000182584000009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Epidemiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClose Contacten_US
dc.subjectDiagnosisen_US
dc.subjectEpidemiological Featuresen_US
dc.subjectTuberculous Meningitisen_US
dc.titleTuberculous meningits in adults in Turkeyen_US
dc.titleTuberculous meningits in adults in Turkey
dc.typeArticleen_US

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