In Silico studies and DNA cleavage, antioxidant, acetylcholinesterase, and butyrylcholinesterase activity evaluation of bis-histamine schiff bases and bis-spinaceamine substituted derivatives

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dc.authorid0000-0003-4163-9962en_US
dc.authorid0000-0002-3001-0635en_US
dc.contributor.authorLolak, Nebih
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorSönmez, Görkem Deniz
dc.contributor.authorTuneğ, Muhammed
dc.contributor.authorDoğan, Aslınur
dc.contributor.authorAkocak, Süleyman
dc.date.accessioned2023-03-20T12:49:20Z
dc.date.available2023-03-20T12:49:20Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractIn this work, a series of seven bis-histamine Schiff bases (H1-H4) and bis-spinaceamine substituted derivatives (SPH1, SPH2, and SPH4) were successfully re-synthesized to evaluate their antioxidant properties by several bioanalytical methods such as DPPH free radical scavenging assay, ABTS radical cation decolorization assay, metal chelating and CUPRAC methods. On the other hand, these compounds were also investigated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and DNAcleavage. The results revealed that all compounds showed, in general, moderate DPPH and ABTS radical scavenging activities, and low metal chelating and CUPRAC activities. Specifically, compound SPH4 showed good DPPH radical scavenging activity with IC50 value of 59.59 mu M, which is better than the BHA and BHT standard values. The best AChE and BChE inhibition results among the tested series were also obtained for compound SPH4 with % inhibition values of 84.51 and 75.89, respectively. Taken together, compound SPH4 might be an interesting lead compound to discover more potent agents against these enzymes.en_US
dc.identifier.citationLolak, N., Boğa, M., Sönmez, G.D., Tuneğ, M., Doğan, A. ve Akocak, S. (2022). In Silico studies and DNA cleavage, antioxidant, acetylcholinesterase, and butyrylcholinesterase activity evaluation of bis-histamine schiff bases and bis-spinaceamine substituted derivatives. Pharmaceutical Chemistry Journal, 55(12), 1338-1344.en_US
dc.identifier.doi10.1007/s11094-022-02581-7
dc.identifier.endpage1344en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85125658797
dc.identifier.scopusqualityQ4
dc.identifier.startpage1338en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s11094-022-02581-7
dc.identifier.urihttps://hdl.handle.net/11468/11452
dc.identifier.volume55en_US
dc.identifier.wosWOS:000765036200005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBoğa, Mehmet
dc.institutionauthorTuneğ, Muhammed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHistamineen_US
dc.subjectSchiff basesen_US
dc.subjectSpinaceamineen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectDNA cleavageen_US
dc.subjectAlzheimeren_US
dc.titleIn Silico studies and DNA cleavage, antioxidant, acetylcholinesterase, and butyrylcholinesterase activity evaluation of bis-histamine schiff bases and bis-spinaceamine substituted derivativesen_US
dc.titleIn Silico studies and DNA cleavage, antioxidant, acetylcholinesterase, and butyrylcholinesterase activity evaluation of bis-histamine schiff bases and bis-spinaceamine substituted derivatives
dc.typeArticleen_US

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