Irisin in coronary bypass surgery

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dc.contributor.authorAydın, Suna
dc.contributor.authorÇatak, Zekiye
dc.contributor.authorEren, Mehmet Nesimi
dc.contributor.authorTopal, Aşkın Ender
dc.contributor.authorAydın, Süleyman
dc.date.accessioned2024-04-24T17:56:52Z
dc.date.available2024-04-24T17:56:52Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: In coronary bypass surgery, after cardiopulmonary bypass is initiated by arterial cannulation in the ascending aorta and venous cannulation through a single vein generally in the right atrium, the process of cooling the patient is started. Objective: There is a relation between cooling the patient and irisin, which is responsible for releasing heat. Therefore, the main objective of the present study is to explore how irisin concentrations and some other panel of myocardium injury in patients undergoing coronary artery bypass surgery. Methods: The blood samples collected before induction (T1), before bypass (T2), before (T3) and after (T4) removing the cross-clamp, upon admission to intensive care (T5), and at the postoperative 24 (T6) and 72 (T7) hours, and whether these concentrations are correlated with lactate levels classically used in monitoring this surgery. A total of biological samples, 23 from control individuals and 105 from bypass patients (14-16 samples for each timeframe) were analyzed to determine irisin, CK-MB, TnT and BNP levels by ELISA and lactate levels by lactate assay kit. Both lactate and irisin were seen to increase gradually from the time of induction to the removal of the cross-clamp. After the cross-clamp was removed and the patient was started to be warmed, both parameters began to decrease gradually and were restored to normal levels on the second and third post-operative days. The increase and decrease in irisin were found correlated with lactate levels. CK-MB, TnT and BNP alteration were similar to each other. Results: Based on these results, it is estimated that measurement of irisin along with lactate may prove to be a useful parameter in monitoring the coronary bypass surgery and irisin may be a significant marker of hypothermia. Beside CK-MB, TnT and BNP, measurements of irisin concentration in open heart surgery may also be useful parameters for the panel of myocardium injury. © 2018 Bentham Science Publishers.en_US
dc.identifier.citationAydın, S., Çatak, Z., Eren, M. N., Topal, A. E. ve Aydın, S. (2018). Irisin in coronary bypass surgery. Cardiovascular and Hematological Disorders - Drug Targets, 18(3), 208-214.
dc.identifier.doi10.2174/1871529X18666180511141151
dc.identifier.endpage214en_US
dc.identifier.issn1871-529X
dc.identifier.issue3en_US
dc.identifier.pmid29749315
dc.identifier.scopus2-s2.0-85055071975
dc.identifier.scopusqualityQ3
dc.identifier.startpage208en_US
dc.identifier.urihttps://doi.org/10.2174/1871529X18666180511141151
dc.identifier.urihttps://hdl.handle.net/11468/23696
dc.identifier.volume18en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofCardiovascular and Hematological Disorders - Drug Targets
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary bypass surgeriesen_US
dc.subjectHypothermiaen_US
dc.subjectIrisinen_US
dc.subjectLactateen_US
dc.subjectMyocardium injuryen_US
dc.subjectPituitary glanden_US
dc.titleIrisin in coronary bypass surgeryen_US
dc.titleIrisin in coronary bypass surgery
dc.typeArticleen_US

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