Electron Microscopic and Histological Evaluation of the Levator Muscle in Patients with Congenital Blepharoptosis

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dc.contributor.authorSoker, Sevda
dc.contributor.authorCakmak, Sevin
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorDeveci, Engin
dc.contributor.authorGul, Mehmet
dc.contributor.authorSoker, Murat
dc.contributor.authorAkkus, Murat
dc.date.accessioned2024-04-24T17:33:47Z
dc.date.available2024-04-24T17:33:47Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To examine the levator muscle in patients with congenital blepharoptosis and to investigate the relationship between those findings and age, gender, and degree of blepharoptosis. STUDY DESIGN: The levator muscles of 13 congenital ptosis patients who had undergone levator muscle resection were examined by light and electron microscopy. During the preoperative period the ptosis amount, levator function, tear function, Bell's phenomenon, and jaw-wink phenomenon were evaluated. RESULTS: There were 9 (69.2%) male and 4 (30.8%) female cases, with an average age of 10.61 +/- 4.77 years (range, 4-19). The quality and quantity of the levator muscle fibrils were assessed by histological examination. There was no relationship detected between histological features of levator palpebralis superior muscle and patients' age and gender (p < 0.05). Patients with a weak levator palpebralis superior muscle had fatty degeneration histologically. Higher levator palpebralis superior muscle function correlated with decreased fatty degeneration and increased skeletal muscle fibrils, but these findings were not statistically significant. There was a reduction in the diameter of muscle fibers and nucleus deformation when muscle function was examined in patients under low-magnification electron microscope. There were lipid droplets of various sizes in some sections, and the mitochondria were seen in mitochondrial crystalline structure depending on cytopathies. In some sections of this group there was large mitochondria and edema formation due to an increase in the mitochondrial matrix. CONCLUSION: More ultrastructural studies in larger populations are needed to support the relationship between structure and function of levator palpebralis superior muscle in patients with congenital blepharoptosis.en_US
dc.identifier.endpage198en_US
dc.identifier.issn0884-6812
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84975529321
dc.identifier.scopusqualityQ4
dc.identifier.startpage195en_US
dc.identifier.urihttps://hdl.handle.net/11468/20838
dc.identifier.volume38en_US
dc.identifier.wosWOS:000399656100008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBirth Defects, Blepharoptosisen_US
dc.subjectCongenital Blepharoptosisen_US
dc.subjectCongenital Defectsen_US
dc.subjectDrooping Eyelid Eyeen_US
dc.subjectLevator Muscle, Electron Microscopyen_US
dc.subjectMicroscopy, Polarized Lighten_US
dc.subjectOculomotor-Levator Synkinesisen_US
dc.subjectOcular Motility Disordersen_US
dc.subjectPtosis, Eyeliden_US
dc.titleElectron Microscopic and Histological Evaluation of the Levator Muscle in Patients with Congenital Blepharoptosisen_US
dc.titleElectron Microscopic and Histological Evaluation of the Levator Muscle in Patients with Congenital Blepharoptosis
dc.typeArticleen_US

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