The clinical features of olanzapine overdose in emergency department; a three years experience

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dc.contributor.authorUestuendag, Mehmet
dc.contributor.authorGueloglu, Cahfer
dc.contributor.authorOrak, Murat
dc.contributor.authorAltunci, Yusuf Ali
dc.contributor.authorDogan, Halil
dc.contributor.authorTamam, Yusuf
dc.date.accessioned2024-04-24T17:38:16Z
dc.date.available2024-04-24T17:38:16Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Since using of olanzapine becomes widespread in the world, clinical features of olanzapine intoxication become important for emergency departments. In our study, we evaluated the patients with Olanzapine intoxication retrospectively. Methods: Olanzapine overdose patients who were admitted to an emergency department between February 2004 and April 2007 were included in the study. The Poisoning Severity Score of the European Association of Poison Centers and Clinical Toxicologists was used to assess intoxication severity. Results: In our study we include fifteen olanzapine overdose patients. Female and male ratio was two (10/5). The average age was 27.33 +/- 9.27 years (range: 17-48 years). The ingested olanzapine doses ranged from 50 to 600 mg whereas the mean of admission time was 3.96 +/- 2.38 (range: 1.5-10) hours after ingestion. For a subgroup of patients ingesting olanzapine alone, The Poisoning Severity Score was 'minor' in four (44.4%), 'moderate' in four (44.4%), and 'severe' in one (11.2%) patients. While minor intoxication symptoms occurred in a broad range of ingested doses (50-75 mg), moderate intoxications were observed at a minimal ingested reported dose of 140 mg. Finally 13 patients were discharged after full recovery and two patients died. Conclusion: Our findings showed that olanzapine overdose is relatively well tolerated especially when it is not accompanied by any co-ingestant. However, it can be life threaten when it is high doses are ingested or in association with other ingestants. There is correlation between dose and clinical features or prognosis. (Anatolian Journal of Psychiatry 2010; 11:145-150)en_US
dc.identifier.endpage150en_US
dc.identifier.issn1302-6631
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-77952208039
dc.identifier.scopusqualityQ3
dc.identifier.startpage145en_US
dc.identifier.urihttps://hdl.handle.net/11468/21385
dc.identifier.volume11en_US
dc.identifier.wosWOS:000276942900009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherCumhuriyet Univ Tip Fak Psikiyatri Anabilim Dalien_US
dc.relation.ispartofAnadolu Psikiyatri Dergisi-Anatolian Journal of Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOlanzapineen_US
dc.subjectIntoxicationen_US
dc.subjectSuicideen_US
dc.subjectClinic Featureen_US
dc.subjectEmergency Departmenten_US
dc.titleThe clinical features of olanzapine overdose in emergency department; a three years experienceen_US
dc.titleThe clinical features of olanzapine overdose in emergency department; a three years experience
dc.typeArticleen_US

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