In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical fingerprints of five Moroccan seaweeds

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dc.authorid0000-0002-2904-5216en_US
dc.authorid0000-0002-2193-8386en_US
dc.authorid0000-0001-8932-4535en_US
dc.contributor.authorGrina, Fatiha
dc.contributor.authorUllah, Zain
dc.contributor.authorKaplaner, Erhan
dc.contributor.authorMoujahid, Abderrahman
dc.contributor.authorEddoha, Rabiaa
dc.contributor.authorNasser, Boubker
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorÖztürk, Mehmet
dc.date.accessioned2023-10-25T11:27:50Z
dc.date.available2023-10-25T11:27:50Z
dc.date.issued2020en_US
dc.departmentDicle Üniversitesi, Bilim ve Teknoloji Uygulama ve Araştırma Merkezien_US
dc.description.abstractThe coastlines of Morocco have an abundant resource of diverse seaweeds but the bioactivity of many of these seaweeds is still unexplored. The aim of this study was to contribute to the evaluation of the antioxidant potential, using different in vitro systems and searching some fingerprints of phenolic constituents based on LC-MS/MS method of five seaweeds species obtained from Moroccan Atlantic Ocean: Bifurcaria bifurcata, Cystoseira humilis, Cystoseira stricta, Fucus spiralis and Gelidium sesquipedale. The total phenolic compounds, the antioxidant activity, anticholinesterase, tyrosinase inhibitory, urease inhibitory activities and the organic compounds were determined. The results showed that Fucus spiralis possessed the highest phenolic and flavonoid contents compared to the others. In addition, Fucus spiralis (IC50: 13.25 ± 0.9 µg/mL) and Cystoseira stricta (IC50: 13.58 ± 1.2 µg/mL) exhibited higher lipid peroxidation inhibitory activity. The highest1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50: 47.23 ± 3.8 µg/mL), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) dia-mmonium salt (ABTS) (IC50: 5.95 ± 0.6 µg/mL), and Cupric reducing antioxidant capacity (CUPRAC) (55.24 ± 0.04 µg trolox equivalents/mg) activity was measured in Fucus spiralis. Regarding metal chelating activity, Bifurcaria bifurcata was the best (IC50: 45.22 ± 0.9 µg/mL) compared to the others. The highest acetylcholinesterase (IC50: 28.92 ± 1.8 µg/mL), butyrylcholinesterase (IC50: 11.72 ± 2.8 µg/mL), tyrosinase (IC50: 6.19 ± 0.4 µg/mL) and urease (IC50: 10.96 ± 1.3 µg/mL) inhibitory activities was found in Fucus spiralis. According to LC-MS/MS results, quinic acid, malic acid, fumaric acid, gallic acid, protocatechuic acid, 4-OH-benzoic acid, hesperidin, were detected in ethanol extracts of the five Moroccan seaweeds. This study demonstrated that seaweeds, particularly Fucus spiralis and Cystoseira stricta could be a promising source of antioxidants and phytochemicals which can be used in cosmetics, pharmaceutical and as nutritional food supplement in food industries to deleterious free radical induced stress, disorder and diseases.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) TUBITAK-BIDEB-2215en_US
dc.identifier.citationGrina, F., Ullah, Z., Kaplaner, E., Moujahid, A., Eddoha, R., Nasser, B. ve diğerleri. (2020). In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical fingerprints of five Moroccan seaweeds. South African Journal of Botany, (128), 152-160.en_US
dc.identifier.doi10.1016/j.sajb.2019.10.021
dc.identifier.endpage160en_US
dc.identifier.issn0254-6299
dc.identifier.scopus2-s2.0-85074949415
dc.identifier.scopusqualityQ1
dc.identifier.startpage152en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0254629919309160?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/12936
dc.identifier.volume128en_US
dc.identifier.wosWOS:000506413200018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErtaş, Abdulselam
dc.institutionauthorÖztürk, Mehmet
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofSouth African Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant activityen_US
dc.subjectEnzymatic activityen_US
dc.subjectLC-MS/MS methoden_US
dc.subjectMacroalgaeen_US
dc.subjectPhenolics compoundsen_US
dc.subjectSeaweed extractsen_US
dc.titleIn vitro enzyme inhibitory properties, antioxidant activities, and phytochemical fingerprints of five Moroccan seaweedsen_US
dc.titleIn vitro enzyme inhibitory properties, antioxidant activities, and phytochemical fingerprints of five Moroccan seaweeds
dc.typeArticleen_US

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