Comparative in vitro activity of plazomicin and older aminoglyosides against Enterobacterales isolates; prevalence of aminoglycoside modifying enzymes and 16S rRNA methyltransferases

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dc.contributor.authorGur, Deniz
dc.contributor.authorHasdemir, Ufuk
dc.contributor.authorCakar, Asli
dc.contributor.authorCavusoglu, Iffet
dc.contributor.authorCelik, Tugce
dc.contributor.authorAksu, Burak
dc.contributor.authorSancak, Banu
dc.date.accessioned2024-04-24T16:11:16Z
dc.date.available2024-04-24T16:11:16Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractComparative in vitro activity of plazomicin and 4 older aminoglycosides was evaluated with broth microdilution in 714 blood isolates from 14 hospitals in Turkey. Isolates included Escherichia coli (n=320), Klebsiella spp. (n=294), Enterobacter spp. (n =69), Serratia marcescens (n=20). and Citrobacter spp. (n=11). Isolates resistant to older aminoglycosides (n=240) were screened for aminoglycoside modifying enzyme genes: aac(6')-Ib, aac(3)-Ia, aac(3)-IIa, ant(2 '')-Ia. Isolates with high MICs for plazomicin (n=41) were screened for 165 rRNA methyltransferase genes (armA, rmtA, rmtB, rmtC, rmtD, rmtE, rmtF, rmtG, rmtH, npmA) and 2 carbapenemase genes (blaOXA-48, blaNDM-1). Overall, resistance to plazomicin, amikacin, netilmicin, gentamicin, and tobramycin was 7.7%, 7.4%, 31.5%, 32.9%, and 34.7%, respectively. aac(6')-Ib and aac(3)-IIa were the most common AME genes. Co-occurrence of blaNDM-1 with armA and rmtC and blaOXA-48 with armA was striking. Enterobacter cloacae carrying rmtC+blaNDM-1, S. marcescens with armA+blaOXA-48, and rmtF+ blaOXA-48 in K. pneumoniae were reported for the first time. (C) 2020 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipAchaogen Inc., CA, USAen_US
dc.description.sponsorshipThe authors would like to acknowledge Achaogen Inc., CA, USA, for providing plazomicin and partly funding the tests for in vitro susceptibilities and characterization of aminoglycoside resistance genes.en_US
dc.identifier.doi10.1016/j.diagmicrobio.2020.115092
dc.identifier.issn0732-8893
dc.identifier.issn1879-0070
dc.identifier.issue4en_US
dc.identifier.pmid32569921
dc.identifier.urihttps://doi.org/10.1016/j.diagmicrobio.2020.115092
dc.identifier.urihttps://hdl.handle.net/11468/15333
dc.identifier.volume97en_US
dc.identifier.wosWOS:000551985300014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKlebsiellaen_US
dc.subjectE. Colien_US
dc.subjectArmaen_US
dc.subjectNdm-1en_US
dc.subjectSerratiaen_US
dc.subject16s Rrna Methyltransferaseen_US
dc.subjectAminoglycoside Resistanceen_US
dc.subjectPlazomicinen_US
dc.subjectAminoglycoside Modifying Enzymeen_US
dc.subjectRmtben_US
dc.subjectRmtaen_US
dc.subjectRmteen_US
dc.subjectRmtfen_US
dc.subjectEnterobacteren_US
dc.subjectOxa-48en_US
dc.subjectRmtcen_US
dc.titleComparative in vitro activity of plazomicin and older aminoglyosides against Enterobacterales isolates; prevalence of aminoglycoside modifying enzymes and 16S rRNA methyltransferasesen_US
dc.titleComparative in vitro activity of plazomicin and older aminoglyosides against Enterobacterales isolates; prevalence of aminoglycoside modifying enzymes and 16S rRNA methyltransferases
dc.typeArticleen_US

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