The relationship between the chemical components and skin-related enzyme inhibition, antioxidant activities and toxicity profile of Helichrysum armenium subsp. armenium

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dc.authorid0000-0002-1697-7380en_US
dc.authorid0000-0001-5829-6914en_US
dc.authorid0000-0002-8544-0683en_US
dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-3060-7271en_US
dc.authorid0000-0001-6548-7823en_US
dc.contributor.authorYıldız, Gülsüm
dc.contributor.authorKaratoprak, Gökçe Şeker
dc.contributor.authorİlgün, Selen
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorKöse, Yavuz Bülent
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2024-03-26T12:34:11Z
dc.date.available2024-03-26T12:34:11Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi Bilim ve Teknoloji Uygulama ve Araştırma Merkezien_US
dc.description.abstractThe aerial parts of Helichrysum armenium subsp. armenium were subjected to methanol, ethyl acetate and n-hexane extraction. The extracts were evaluated for their in vitro enzyme inhibitory activity [lipoxygenase (LOX), tyrosinase and elastase], antioxidant activity and toxicity (on fibroblast cells). All the extracts displayed a weak effect on LOX and elastase. The ethyl acetate extract showed the highest inhibition on tyrosinase enzyme with IC50 = 460 µg/mL, while kojic acid had IC50 = 30 µg/mL. The methanol and ethyl acetate extracts compared to the n-hexane extract exhibited stronger DPPH• and ABTS•+ scavenging activity, as well as iron(II)-chelating potential, and were shown to have rich phenolic and flavonoid contents. The methanol extract was toxic to healthy fibroblast cells at a higher concentration with IC50 > 500 µg/mL compared to the other extracts. Phytochemical analysis of the extracts was made quantitatively by LC–MS/MS. The major components identified in the methanol and the ethyl acetate extracts were astragalin, quinic acid, apigenin-7-glycoside, isoquercitrin, chlorogenic acid, naringenin, apigenin and luteolin-7-glucoside. The compounds detected in the n-hexane extract were much fewer. Based on these findings, H. armenium subsp. armenium can be considered to be a natural raw material with the potential to be used in the cosmetic industry.en_US
dc.identifier.citationYıldız, G., Karatoprak, G. Ş., İlgün, S., Yılmaz, M. A., Köse, Y. B. ve Zengin, G. (2023). The relationship between the chemical components and skin-related enzyme inhibition, antioxidant activities and toxicity profile of Helichrysum armenium subsp. armenium. Plant Biosystems, 158(1), 119-129.en_US
dc.identifier.doi10.1080/11263504.2023.2287587
dc.identifier.endpage129en_US
dc.identifier.issn1126-3504
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85179998925
dc.identifier.scopusqualityQ1
dc.identifier.startpage119en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/11263504.2023.2287587
dc.identifier.urihttps://hdl.handle.net/11468/13727
dc.identifier.volume158en_US
dc.identifier.wosWOS:001124654500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofPlant Biosystems
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitoryen_US
dc.subjectHelichrysum armenium subsp. armeniumen_US
dc.subjectLC–MS/MSen_US
dc.subjectToxicityen_US
dc.titleThe relationship between the chemical components and skin-related enzyme inhibition, antioxidant activities and toxicity profile of Helichrysum armenium subsp. armeniumen_US
dc.titleThe relationship between the chemical components and skin-related enzyme inhibition, antioxidant activities and toxicity profile of Helichrysum armenium subsp. armenium
dc.typeArticleen_US

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