Organogels as novel carriers for dermal and topical drug delivery vehicles

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dc.contributor.authorUzan, Serhat
dc.contributor.authorBaris, Deniz
dc.contributor.authorColak, Mehrnet
dc.contributor.authorAydin, Haluk
dc.contributor.authorHosgoren, Halil
dc.date.accessioned2024-04-24T16:18:26Z
dc.date.available2024-04-24T16:18:26Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractAminoalcohol based bis-(aminoalcohol)oxalamides (BAOAs) (1,6-amino alcohol=leucinol, isoleucinol, valinol, phenyiglycinol, phenylalaninol and 2-amino-1-butanol) have been explored to develop drug depot systems and illustrated as a novel dermal and topical drug delivery vehicle for non-steroidal anti-inflammatory drug molecules. FAE's (Fatty acid ethyl and isopropyl esters) with different chain lengths, ethyl laurate, ethyl myristate, ethyl palmitate, isopropyl laurate, isopropyl myristate, isopropyl palmitate, have been chosen as they are biocompatible organic fluids used typically in cosmetic industry. Ibuprofen (Ib), acting as a model drug, was entrapped in the supramolecular organogels. The release behavior of Ib molecules in the supramolecular organogels was investigated by using UV-vis spectroscopy. The influence of the organogelator and drug concentration, pH values of the accepting media, and nature of solvent (different FAE's) on the release behavior of Ib was investigated under static conditions. The results indicated that the release rate of Ib from the supramolecular organogels was effectively retarded with an increase of the organogelator concentration. Also, the release rates of Ib increased on increasing the Ib content. Furthermore, the release behavior of Ib was found to be different at various pH values in buffers as accepting media. The study of the release kinetics indicated that the release behavior of Ib was in accord with the Higuchi equation and the diffusion-controlled mechanism involved in the Fickian model. These observations indicate that bis-(aminoalcohol)oxalamides gels may act as delivery vehicles for non-steroidal anti-inflammatory drug molecules and also show that the release profiles for such systems can be fine-tuned by the correct choice of gelator-FAE combination. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [1132142, 113Z142]; Dicle University, Research and Project Coordination [13-FF-73]en_US
dc.description.sponsorshipWe would like to thank The Scientific and Technological Research Council of Turkey (1132142) (TUBITAK) for financially supporting this research (Project No. 113Z142). And we extend our thanks to the Dicle University, Research and Project Coordination for their support to our Project (No: 13-FF-73).en_US
dc.identifier.doi10.1016/j.tet.2016.10.009
dc.identifier.endpage7525en_US
dc.identifier.issn0040-4020
dc.identifier.issue47en_US
dc.identifier.scopus2-s2.0-84994152008
dc.identifier.scopusqualityQ3
dc.identifier.startpage7517en_US
dc.identifier.urihttps://doi.org/10.1016/j.tet.2016.10.009
dc.identifier.urihttps://hdl.handle.net/11468/16090
dc.identifier.volume72en_US
dc.identifier.wosWOS:000387525900017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTetrahedron
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGelsen_US
dc.subjectLmwogs (Low Molecular Weight Organojelators)en_US
dc.subjectControlled Releaseen_US
dc.subjectDrug Delivery Systemsen_US
dc.subjectFormulationen_US
dc.subjectFormulation Vehicleen_US
dc.subjectFtiren_US
dc.titleOrganogels as novel carriers for dermal and topical drug delivery vehiclesen_US
dc.titleOrganogels as novel carriers for dermal and topical drug delivery vehicles
dc.typeArticleen_US

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