Genetics Analysis with Down Syndrome and Histopathological Examination of Buccal Epithelial Cells

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dc.contributor.authorKalkanli, S.
dc.contributor.authorSimsek, S.
dc.contributor.authorBalkan, M.
dc.contributor.authorAkbas, H.
dc.contributor.authorIsi, H.
dc.contributor.authorOral, D.
dc.contributor.authorTurkyilmaz, A.
dc.date.accessioned2024-04-24T17:34:03Z
dc.date.available2024-04-24T17:34:03Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractDown syndrome is primarily caused by trisomy of chromosome 21. We reviewed cytogenetic studies performed on 1048 patients who were referred to the Cytogenetics Unit at Dicle University Hospital, Diyarbakir, Southeast Turkey, between 2000 and 2009. The cases were grouped according to the reason of referral for cytogenetic analysis. The highest frequencies of abnormal karyotypes were found among cases that were referred due to suspicion of Down syndrome (84.8%). For histologic examination to persons with Down syndrome and normal, buccal mucosa smear was prepared by rubbing. Down syndrome are disabled and control groups were compared statistically buccal epithelial cells and nuclei (p<0.05). Periphery of the nucleus in some patients with Down's syndrome, while the bud structures in the form of micronuclei was observed in the karyolytic cells.en_US
dc.identifier.endpage671en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84884795975
dc.identifier.scopusqualityQ3
dc.identifier.startpage668en_US
dc.identifier.urihttps://hdl.handle.net/11468/20935
dc.identifier.volume31en_US
dc.identifier.wosWOS:000327763000053
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDown Syndromeen_US
dc.subjectBuccal Mucosaen_US
dc.subjectSoutheast Turkeyen_US
dc.subjectChromosomal Abnormalitiesen_US
dc.subjectGenetic Counselingen_US
dc.titleGenetics Analysis with Down Syndrome and Histopathological Examination of Buccal Epithelial Cellsen_US
dc.titleGenetics Analysis with Down Syndrome and Histopathological Examination of Buccal Epithelial Cells
dc.typeArticleen_US

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