Well designed iridium-phosphinite complexes: Biological assays, electrochemical behavior and density functional theory calculations

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dc.authorid0000-0001-8028-2244en_US
dc.authorid0000-0003-0456-5124en_US
dc.authorid0000-0002-2488-0378en_US
dc.authorid0000-0002-5505-2700en_US
dc.authorid0000-0002-7418-0564en_US
dc.contributor.authorKhadichakhan Rafikova
dc.contributor.authorMeriç, Nermin
dc.contributor.authorBinbay, Nil Ertekin
dc.contributor.authorOkumuş, Veysi
dc.contributor.authorErdem, Kemal
dc.contributor.authorBelyankova, Yelizaveta
dc.contributor.authorGüzel, Remziye
dc.date.accessioned2024-07-01T12:37:15Z
dc.date.available2024-07-01T12:37:15Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractMononuclear phosphinite Iridium complexes based on ferrocene group have been prepared and characterized by various spectroscopic techniques. The complexes were subjected to cyclic voltammetry studies in order to determine the energies of HOMO and LUMO levels and to estimate their electrochemical and some electronic properties. Organic complex-based memory substrates were immobilized using TiO2-modified ITO electrodes, and the memory functions of phosphinite-based organic complexes were verified by chronoamperometry (CA) and open-circuit potential amperometry (OCPA). Extensive theoretical and experimental investigations were directed to gain a more profound understanding of the chemical descriptors and the diverse electronic transitions taking place within the iridium complexes, as well as their electrochemical characteristics. The quantum chemical calculations were carried out for the iridium complexes at the DFT/CAM-B3LYP level of theory in the gas phase. Furthermore, the antioxidant, antimicrobial, DNA binding, and DNA cleavage activities of the complexes were tested. Complex 2 exhibited the highest radical scavenging activity (67.5 ± 2.24 %) at 200.0 mg/L concentration. It was observed that the complexes formed an inhibition zone in the range of 8–15 mm against Gram + bacteria and in the range of 0–13 mm against Gram – bacteria. The agarose gel electrophoresis method was used to determine the DNA binding and DNA cleavage activities of the complexes. All of the tested complexes had DNA binding activity; however, complexes 1, 2, and 8 showed better binding activity than the others.en_US
dc.identifier.citationRafikova, K., Meriç, N., Binbay, N. E., Okumuş, V., Erdem, K., Belyankova, Y. ve diğerleri. (2024). Well designed iridium-phosphinite complexes: Biological assays, electrochemical behavior and density functional theory calculations. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 318, 1-13.en_US
dc.identifier.endpage13en_US
dc.identifier.issn1386-1425
dc.identifier.pmid38763019
dc.identifier.scopus2-s2.0-85193423872
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1386142524006140?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/28693
dc.identifier.volume318en_US
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.institutionauthorMeriç, Nermin
dc.institutionauthorBinbay, Nil Ertekin
dc.institutionauthorGüzel, Remziye
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
dc.relation.isversionof10.1016/j.saa.2024.124448en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological assaysen_US
dc.subjectDFT calculationen_US
dc.subjectElectrochemical behavioren_US
dc.subjectFerrocene groupen_US
dc.subjectIridiumen_US
dc.subjectPhosphinite liganden_US
dc.titleWell designed iridium-phosphinite complexes: Biological assays, electrochemical behavior and density functional theory calculationsen_US
dc.titleWell designed iridium-phosphinite complexes: Biological assays, electrochemical behavior and density functional theory calculations
dc.typeArticleen_US

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