CHANGE OF ANTIOXIDANT ENZYME ACTIVITIES, SOME METALS AND LIPID PEROXIDATION IN ALZHEIMER'S DISEASE

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dc.contributor.authorArslan, Ayse
dc.contributor.authorTuzun, Fatma Aykan
dc.contributor.authorTamer, Sibel
dc.contributor.authorDemir, Halit
dc.contributor.authorAycan, Abdurrahman
dc.contributor.authorDemir, Canan
dc.contributor.authorTasin, Muhterem
dc.date.accessioned2024-04-24T17:18:22Z
dc.date.available2024-04-24T17:18:22Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive regression and memory loss. It has been claimed that oxidative stress and factors such as metal accumulation in the brain play important roles in the etiopathogenesis of the disease. Material and methods: The subjects of this study consisted of 24 individuals with Alzheimer's disease and 15 healthy agematched controls. Blood samples were withdrawn from the patients and healthy controls, and the activities of antioxidant enzymes SOD (Superoxide Dismutase), GSH (Glutathion), GSHPx (Glutathion peroxidase), GST (Glutathion S-Transferase) and MDA (Malondialdehyde) levels were determined by Spectrometer. Some metals and heavy metals were measured by atomic absorption spectrometry (AAS). Results: Biochemical analyses showed a significant decrease of the main enzymatic antioxidant defences (SOD, GSH, GST and GSHPx) and increased production of lipid peroxidation marker (MDA) in the serum of AD patients, compared to age-matched control group (p< 0.001). Also the levels of Zn, Mg, and Mn was lower and Fe, Pb, and Cd was higher in the patient group, compared to the control group. Serum Cu and Co levels did not differ significantly between the patient and control groups (p> 0.001). Conclusion: These results supports the theory that in AD there is a defect in the antioxidant defense system, which may lead to oxidative damage. Also alterations in some trace metals and their related enzymes may play a role of etiopathogenesis in AD.en_US
dc.identifier.doi10.19193/0393-6384_2016_5_144
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84992188146
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2016_5_144
dc.identifier.urihttps://hdl.handle.net/11468/18751
dc.identifier.volume32en_US
dc.identifier.wosWOS:000390172000015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectAntioxidantsen_US
dc.subjectSerum Metalsen_US
dc.subjectHeavy Metalsen_US
dc.subjectLipid Peroxidationen_US
dc.titleCHANGE OF ANTIOXIDANT ENZYME ACTIVITIES, SOME METALS AND LIPID PEROXIDATION IN ALZHEIMER'S DISEASEen_US
dc.titleCHANGE OF ANTIOXIDANT ENZYME ACTIVITIES, SOME METALS AND LIPID PEROXIDATION IN ALZHEIMER'S DISEASE
dc.typeArticleen_US

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