The effects of recombinant human bone morphogenic protein-2 and low-level laser irradiation on synthetic graft healing in a rat bony defect model

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dc.contributor.authorKoparal, Mahmut
dc.contributor.authorKose, Ibrahim
dc.contributor.authorAtalay, Yusuf
dc.contributor.authorCakmak, Omer
dc.contributor.authorAlan, Hilal
dc.contributor.authorAgacayak, Kamil Serkan
dc.contributor.authorErdogdu, Ibrahim Halil
dc.date.accessioned2024-04-24T17:38:24Z
dc.date.available2024-04-24T17:38:24Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe assessed the benefit of bone morphogenic protein-2 (BMP-2) and low-level laser irradiation (LLLI) on the osseointegration of synthetic bone grafts. Synthetic bone grafts are safe alternatives to autografts. BMP-2 and LLLI have been shown separately to improve bone healing. However, their effects have not been evaluated together with synthetic materials. Here, we used a rat model to compare the efficacy of BMP-2 and LLLI on synthetic graft healing. Male Sprague-Dawley rats (n = 35) were divided equally into groups: control (defect only), graft only, graft and BMP-2, graft and LLLI, and a combination of graft, LLLI, and BMP-2. A 3 x 3 mm monocortical tibial defect was filled using a synthetic graft with or without 2 mg/mL BMP-2 pre-treatment. LLLI was performed using an optical fibre and an indium-gallium-arsenide-phosphate laser for 60 s daily for 7 days, delivering 6.0 J/day. Histopathology was performed 4 weeks post-graft using a standardised scoring system (1-5, based on the degree of healing observed). Groups were compared using the MannWhitney U test, with p values < 0.05 considered significant. Osteogenesis was poor in both the control and graft-only groups (1.4 +/- 0.5 and 2.3 +/- 0.5, respectively). BMP-2-(4.3 +/- 0.5), LLLI-(3.7 +/- 0.5), and BMP-2/LLLI-treated (4.7 +/- 0.5) grafts all displayed significantly more healing than the control or graft alone groups (P < 0.001). Both BMP-2 and LLLI significantly improved the osseointegration of synthetic bone grafts. However, no synergy was noted between the therapies.en_US
dc.identifier.endpage15718en_US
dc.identifier.issn1940-5901
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-84985930568
dc.identifier.scopusqualityN/A
dc.identifier.startpage15709en_US
dc.identifier.urihttps://hdl.handle.net/11468/21435
dc.identifier.volume9en_US
dc.identifier.wosWOS:000385837700078
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Healingen_US
dc.subjectExperimental Surgeryen_US
dc.subjectLow-Level Laser Therapyen_US
dc.subjectDiode Laseren_US
dc.titleThe effects of recombinant human bone morphogenic protein-2 and low-level laser irradiation on synthetic graft healing in a rat bony defect modelen_US
dc.titleThe effects of recombinant human bone morphogenic protein-2 and low-level laser irradiation on synthetic graft healing in a rat bony defect model
dc.typeArticleen_US

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