Relationship of PCNA, C-erbB2 and CD44s expression with tumor grade and stage in urothelial carcinomas of the bladder

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dc.contributor.authorYildirim, Ayhan
dc.contributor.authorKosem, Mustafa
dc.contributor.authorSayar, Ilyas
dc.contributor.authorGelincik, Ibrahim
dc.contributor.authorYavuz, Alparslan
dc.contributor.authorBozkurt, Aliseydi
dc.contributor.authorErkorkmaz, Unal
dc.date.accessioned2024-04-24T17:49:50Z
dc.date.available2024-04-24T17:49:50Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn the present study, the intention was to reveal the relationship of histological grade and stage with c-erbB2, CD44s, and PCNA immunoreactivity in bladder urothelial carcinomas (UC). In our study, we evaluated 46 items of transurethral resection material of patients submitted by YYU Faculty of Medicine, Main Department of Pathology, with a mass revealed in their bladder after clinical and radiological studies at our laboratories and who were diagnosed with urothelial carcinomas. PCNA, c-erbB2, and CD44s were applied in an immunohistochemical manner comprised from nine low-malignant potential papillary urothelial neoplasia, 23 low-grade papillary urothelial carcinoma, and 14 high-grade papillary urothelial carcinoma. Immunostaining was scored according to the percentage of positive cells. The immunohistochemical study demonstrated that the c-erbB2 and PCNA staining ratio increased when an increase occurred in stage and grade. The CD44s staining ratio decreased. C-erbB2, PCNA, and CD44s appear to be a useful marker in the assessment of the prognosis and treatment options in urothelial carcinomas.en_US
dc.identifier.endpage1523en_US
dc.identifier.issn1940-5901
dc.identifier.issue6en_US
dc.identifier.pmid25035774
dc.identifier.startpage1516en_US
dc.identifier.urihttps://hdl.handle.net/11468/23018
dc.identifier.volume7en_US
dc.identifier.wosWOS:000341255900004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrothelial Carcinomasen_US
dc.subjectPcnaen_US
dc.subjectCd44en_US
dc.subjectC-Erbb2en_US
dc.subjectImmunohistochemical Studyen_US
dc.titleRelationship of PCNA, C-erbB2 and CD44s expression with tumor grade and stage in urothelial carcinomas of the bladderen_US
dc.titleRelationship of PCNA, C-erbB2 and CD44s expression with tumor grade and stage in urothelial carcinomas of the bladder
dc.typeArticleen_US

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