Investigation of the Effects of Leptin on the Cardiovascular System in Patients With Systemic Sclerosis

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dc.contributor.authorAtilgan, Zuhal Ariturk
dc.contributor.authorIslamoglu, Yahya
dc.contributor.authorTekbas, Ebru
dc.contributor.authorBudulgan, Mahmut
dc.contributor.authorBatmaz, Ibrahim
dc.contributor.authorTahtasiz, Mehmet
dc.contributor.authorYuksel, Hatice
dc.date.accessioned2024-04-24T17:24:27Z
dc.date.available2024-04-24T17:24:27Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Cardiac involvement in systemic sclerosis can be seen, and often remains silent. Leptin, which is often associated with hypertension and regulation of sympathetic tone, has been reported to contribute to the development of atherosclerosis, endothelial dysfunction and thrombosis by acting directly. The aim of this study was to investigate the effects of leptin on the cardiovascular system in patients with systemic sclerosis. Materials and Methods: Twenty-seven patients with systemic sclerosis and 28 healthy subjects as a control group were included in the study. Clinical and laboratory parameters, 24-hour Holter ECG and ambulatory blood pressure monitorings were recorded and serum leptin levels were measured in all subjects. Results: Mean leptin levels were lower in patients with systemic sclerosis than in controls. In 24-hour ambulatory blood pressure Holter recordings, the mean systolic and diastolic blood pressure, daytime systolic and diastolic blood pressure, systolic and diastolic blood pressure values at night were lower in patients when compared with controls. There was no relationship between leptin and heart rate variability parameters. A positive correlation was found between leptin levels and 24-hour ambulatory blood pressure parameters. Conclusion: Decreased serum leptin levels and increased mean heart rate in patients with systemic sclerosis may be the result of increased sympathetic tone.en_US
dc.identifier.doi10.4274/tftr.36450
dc.identifier.endpage324en_US
dc.identifier.issn1302-0234
dc.identifier.issn1308-6316
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84891645498
dc.identifier.scopusqualityN/A
dc.identifier.startpage319en_US
dc.identifier.urihttps://doi.org/10.4274/tftr.36450
dc.identifier.urihttps://hdl.handle.net/11468/19683
dc.identifier.volume59en_US
dc.identifier.wosWOS:000340589000010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurkiye Fiziksel Tip Ve Rehabilitasyon Dergisi-Turkish Journal of Physical Medicine and Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSystemic Sclerosisen_US
dc.subjectLeptinen_US
dc.subject24-Hour Holter Monitoringen_US
dc.titleInvestigation of the Effects of Leptin on the Cardiovascular System in Patients With Systemic Sclerosisen_US
dc.titleInvestigation of the Effects of Leptin on the Cardiovascular System in Patients With Systemic Sclerosis
dc.typeArticleen_US

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