Synthesis, photophysical and antioxidant properties of carbazole-based bis-thiosemicarbazones

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dc.contributor.authorBingul, Murat
dc.contributor.authorSenkuytu, Elif
dc.contributor.authorSaglam, Mehmet F.
dc.contributor.authorBoga, Mehmet
dc.contributor.authorKandemir, Hakan
dc.contributor.authorSengul, Ibrahim F.
dc.date.accessioned2024-04-24T16:02:19Z
dc.date.available2024-04-24T16:02:19Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractUtilizing Schiff base condensation of the 9-ethylcarbazole-3,6-dicarbaldehyde and thiosemicarbazides, four new N-ethylcarbazole-based bis-thiosemicarbazone compounds 4a-d were successfully synthesized in high yields. The photophysical properties of the targeted compounds 4a-d were investigated using UV-vis absorption and fluorescence emission spectroscopy. The antioxidant properties of targeted compounds 4a-d were determined by DPPH radical scavenging, ABTS Cation Radical Decolarization and CUPRAC Cupric Reducing Antioxidant Capacity assay methods. Moreover, the anti-cholinesterase properties of designated compounds were investigated by the Acetylcholinesterase (Ach) and Butyrylcholinesterase (BCh) enzyme inhibition assays. The compound 4a was determined as a valuable candidate to be a potent antioxidant agent for the DPPH and ABTS assays. The compound 4d was found to be a target compound for the kinetic measurements to identify the mechanism of action in the area of anticholinesterase activity assay.en_US
dc.description.sponsorshipDicle University Scientific Research Project Coordinator (DUBAP Project) [ECZ 15.007]en_US
dc.description.sponsorshipI thank the Dicle University Scientific Research Project Coordinator (DUBAP Project Number: ECZ 15.007) for the financial support given to the research project.en_US
dc.identifier.doi10.1007/s11164-019-03844-x
dc.identifier.endpage4499en_US
dc.identifier.issn0922-6168
dc.identifier.issn1568-5675
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85065244657
dc.identifier.scopusqualityQ2
dc.identifier.startpage4487en_US
dc.identifier.urihttps://doi.org/10.1007/s11164-019-03844-x
dc.identifier.urihttps://hdl.handle.net/11468/14745
dc.identifier.volume45en_US
dc.identifier.wosWOS:000481805000016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofResearch on Chemical Intermediates
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbazoleen_US
dc.subjectThiosemicarbazoneen_US
dc.subjectAntioxidant Activitiesen_US
dc.subjectPhotophysical Propertiesen_US
dc.titleSynthesis, photophysical and antioxidant properties of carbazole-based bis-thiosemicarbazonesen_US
dc.titleSynthesis, photophysical and antioxidant properties of carbazole-based bis-thiosemicarbazones
dc.typeArticleen_US

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