Fusidic Acid Resistance in Staphylococcus aureus Strains in an Interval of Ten Years (2001-2011)

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dc.contributor.authorNergiz, Sebnem
dc.contributor.authorAtmaca, Selahattin
dc.contributor.authorOzekinci, Tuncer
dc.contributor.authorTekin, Alicem
dc.date.accessioned2024-04-24T17:27:37Z
dc.date.available2024-04-24T17:27:37Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Fusidic acid is a steroid-like antibiotic which is used alone or consecutively in combination with other antimicrobial drugs in the treatment of staphylococcal infections, including the strains resistant to methicillin. In this study, we aimed to compare fusidic acid resistance rates in Staphylococcus aureus [methicillin susceptible Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA)] strains isolated in our hospital's clinical microbiology laboratory at an interval of ten years. Material and Methods: Bacterial strains were identified by conventional methods and BD PhoenixTM Automated Microbiology System (BD Diagnostic Systems, Sparks, MD). Methicillin and fusidic acid susceptibilities of the identified S. aureus strains were determined according to Clinical and Laboratory Standards Institute (CLSI) criteria. In order to determine methicillin and fusidic acid susceptibilities, 1 mu g oxacillin and 10 mu g fusidic acid disks (Oxoid Ltd., Basingstoke, United Kingdom) were used. Oxacillin susceptibility was detected according to the criteria of CLSI, and inhibition zone of >= 13 mm was considered as sensitive, 11-12 mm as intermediate, <= 10 mm as resistant. Fusidic acid susceptibility was detected according to the criteria of Comite de L'antibiogramme de la Societe Francaise de Microbiologie, and inhibition zone of 22 mm was considered as sensitive, 16-21 mm as intermediate, <= 15 mm as resistant. Results: In a study carried out ten years ago, fusidic acid resistance rate in S. aureus strains was reported as 11.6%, whereas in our study it was found as 14.6%. There was not any significant difference between the two resistance rates (p=0.695). Fusidic acid resistance rates were found to be 4.2% and 5.7%, respectively in the years 2001 and 2011 for MSSA strains. In MRSA strains, however, the rates were found as 18.9% and 22.2%, respectively. No significant difference was noted between fusidic acid resistances of MSSA and MASA strains, studied at the two different periods (p=1.00, p=0.906). Conclusion: In the light of these findings, it has been concluded that fusidic acid is still a good alternative drug in the treatment of all staphylococcal infections, including methicillin resistant strains.en_US
dc.identifier.doi10.5336/medsci.2011-27892
dc.identifier.endpage1672en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84868324281
dc.identifier.scopusqualityQ4
dc.identifier.startpage1668en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2011-27892
dc.identifier.urihttps://hdl.handle.net/11468/20093
dc.identifier.volume32en_US
dc.identifier.wosWOS:000314145000024
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFusidic Aciden_US
dc.subjectStaphylococcus Aureusen_US
dc.titleFusidic Acid Resistance in Staphylococcus aureus Strains in an Interval of Ten Years (2001-2011)en_US
dc.titleFusidic Acid Resistance in Staphylococcus aureus Strains in an Interval of Ten Years (2001-2011)
dc.typeArticleen_US

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