Protein C and antithrombin III in children with acute leukemia.

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dc.contributor.authorAtlihan F.
dc.contributor.authorKarakaş Z.
dc.contributor.authorBatun S.
dc.date.accessioned2024-04-24T18:44:08Z
dc.date.available2024-04-24T18:44:08Z
dc.date.issued1993
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study Protein C (PC) and antithrombin III (AT III) levels in childhood acute leukemia were investigated. The mean PC activity levels in 19 newly diagnosed cases of acute leukemia were significantly lower as compared with the normal controls (p < 0.05). A significant increase was found (p < 0.01) in the patients in remission. Prior to treatment 78.8 percent of patients had decreased PC activity levels, but all patients had normal PC activity during remission. Decreased PC activity levels were found to be independent of the leukocyte count and liver function. No statistically significant difference was found in the AT III antigen levels between the untreated patients, the patients in remission and the control group. Our results indicate that apart from thrombocytopenia, low PC activity levels and alterations in fibrinolysis and coagulation may be responsible for the hemorrhagic manifestations observed in cases of acute leukemia.en_US
dc.identifier.endpage51en_US
dc.identifier.issn0041-4301
dc.identifier.issue1en_US
dc.identifier.pmid8236517
dc.identifier.scopus2-s2.0-0027344316
dc.identifier.scopusqualityQ3
dc.identifier.startpage45en_US
dc.identifier.urihttps://hdl.handle.net/11468/24576
dc.identifier.volume35en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofThe Turkish journal of pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleProtein C and antithrombin III in children with acute leukemia.en_US
dc.titleProtein C and antithrombin III in children with acute leukemia.
dc.typeArticleen_US

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