The Effects of Caffeic Acid Phenethyl Ester and Ellagic Acid on the Levels of Malondialdehyde, Reduced Glutathione and Nitric Oxide in the Lung, Liver and Kidney Tissues in Acute Diazinon Toxicity in Rats

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dc.contributor.authorAlp, Harun
dc.contributor.authorAytekin, Ismail
dc.contributor.authorAtakisi, Onur
dc.contributor.authorHatipoglu, Namik Kemal
dc.contributor.authorBasarali, Kemal
dc.contributor.authorOgun, Metin
dc.contributor.authorBuyukbas, Sadik
dc.date.accessioned2024-04-24T17:38:22Z
dc.date.available2024-04-24T17:38:22Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of Caffeic Acid Phenethyl Ester (CAPE) and Ellagic Acid (EA) on acitivities of Malondialdehyde (MDA), reduced Glutathione (GSH) and Nitric Oxide (NO) in rat lung, liver and kidney tissues in acute Diazinon (DI) toxicity. Six groups of 6 Sprague Dawley rats were used comprising control, CAPE, EA, DI control, DI+CAPE and DI+EA. Tissue samples were analysed for GSH, MDA and NO levels in lung, liver and kidney tissues. Biochemical parameters were measured colormetrically by spectrophotometer. Control, CAPE and EA groups showed no statistically significant difference whereas DI+medication groups revealed that CAPE and EA increased the level of GSH in liver tissue by blocking the DI effect. NO levels in lung, liver and kidney tissues were significantly increased by DI but CAPE and EA attenuated those levels. In DI+medication groups, MDA levels showed no significant change in kidney and liver tissues but in lung tissues, CAPE and EA reduced the MDA level by blocking the DI effect. It was concluded that CAPE and EA which showed similar effects to each other could be used for protection and support against oxidative stress caused by acute DI intoxication.en_US
dc.identifier.endpage1494en_US
dc.identifier.issn1680-5593
dc.identifier.issn1993-601X
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-80052083986
dc.identifier.scopusqualityN/A
dc.identifier.startpage1488en_US
dc.identifier.urihttps://hdl.handle.net/11468/21420
dc.identifier.volume10en_US
dc.identifier.wosWOS:000298089700024
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherMedwell Onlineen_US
dc.relation.ispartofJournal of Animal and Veterinary Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectDiazinonen_US
dc.subjectEllagic Aciden_US
dc.subjectMalondialdehydeen_US
dc.subjectNitric Oxideen_US
dc.subjectReduced Glutathioneen_US
dc.titleThe Effects of Caffeic Acid Phenethyl Ester and Ellagic Acid on the Levels of Malondialdehyde, Reduced Glutathione and Nitric Oxide in the Lung, Liver and Kidney Tissues in Acute Diazinon Toxicity in Ratsen_US
dc.titleThe Effects of Caffeic Acid Phenethyl Ester and Ellagic Acid on the Levels of Malondialdehyde, Reduced Glutathione and Nitric Oxide in the Lung, Liver and Kidney Tissues in Acute Diazinon Toxicity in Rats
dc.typeArticleen_US

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