Serum levels of neopterin, tumor necrosis factor-alpha and Interleukin-6 in preeclampsia: relationship with disease severity

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dc.contributor.authorOzler, A.
dc.contributor.authorTurgut, A.
dc.contributor.authorSak, M. E.
dc.contributor.authorEvsen, M. S.
dc.contributor.authorSoydinc, H. E.
dc.contributor.authorEvliyaoglu, O.
dc.contributor.authorGul, T.
dc.date.accessioned2024-04-24T17:44:40Z
dc.date.available2024-04-24T17:44:40Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: There are many studies evaluating the role of inflammation in the pathogenesis of preeclampsia. However, little is known about the relationship between the severity of inflammation and the severity of preeclampsia due to insufficient of studies reporting this matter. To investigate the maternal serum concentrations of IL-6, TNF-alpha and Neopterin in patients with mild preeclampsia and severe preeclampsia and HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome in preeclampsia and determine their association with the severity of the disease. PATIENTS AND METHODS: Patients, hospitalized with the diagnosis of preeclampsia between October 2011 and March 2012, were included in the study. The patients with preeclampsia were divided into three groups as mild preeclampsia, severe preeclampsia and HELLP syndrome. The control group was comprised of normotensive and uncomplicated pregnant women. The serum levels of IL-6, TNF-alpha and Neopterin (NEO) were determined, using enzyme-linked immunosorbent assay. Spearman's rank correlation tests were used for the correlations between the serum levels of inflammatory markers and the severity of preeclampsia. RESULTS: There was no observed significant difference among mean serum TNF-alpha and IL-6 levels of four groups (p > 0.05). The median serum concentration of NEO in subjects with mild preeclampsia of 14.1 nmol/L and severe preeclampsia of 14.8 nmol/L was significantly higher than that of 10.3 nmol/L in normotensive controls (p = 0.013; p = 0.000 respectively). In addition, the median serum concentration of NEO was detected to be highest in subjects with HELLP syndrome. The serum levels of NEO was well correlated with the severity of preeclampsia (r = 0.533, p = 0.000). CONCLUSIONS: The serum levels of NEO, an important marker of cellular immunity, associated with severity of disease in patients with preeclampsia.en_US
dc.description.sponsorshipTeva Santeen_US
dc.description.sponsorshipWriting support was provided by Elizabeth V Hillyer with financial support from Teva Sante.en_US
dc.identifier.endpage1712en_US
dc.identifier.issn1128-3602
dc.identifier.issue12en_US
dc.identifier.pmid23161044
dc.identifier.startpage1707en_US
dc.identifier.urihttps://hdl.handle.net/11468/22220
dc.identifier.volume16en_US
dc.identifier.wosWOS:000312113900012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectHellp Syndromeen_US
dc.subjectIl-6en_US
dc.subjectTumor Necrosis Factor-Alphaen_US
dc.subjectTnf-Alphaen_US
dc.subjectNeopterinen_US
dc.titleSerum levels of neopterin, tumor necrosis factor-alpha and Interleukin-6 in preeclampsia: relationship with disease severityen_US
dc.titleSerum levels of neopterin, tumor necrosis factor-alpha and Interleukin-6 in preeclampsia: relationship with disease severity
dc.typeArticleen_US

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