Comparison of binding properties of a novel non-steroidal anti-inflammatory agent and ibuprofen to cyclooxygenase-1 and cyclooxygenase-2 enzymes by saturation transfer difference nuclear magnetic resonance

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dc.contributor.authorBinbay, Nil E.
dc.contributor.authorZiyadanogullari, Berrin
dc.date.accessioned2024-04-24T17:11:59Z
dc.date.available2024-04-24T17:11:59Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description33rd International Physics Conference of Turkish-Physical-Society (TPS) -- SEP 06-10, 2017 -- Konacik, TURKEYen_US
dc.description.abstractSaturation transfer difference nuclear magnetic resonance is a ligand-based screening technique that focuses directly on the physical interaction of a macromolecule (protein, enzyme, etc.) and a small ligand. It is a powerful tool in pharmaceutical research. Here, a comparison is reported of the binding characteristics of ibuprofen and a novel anti-inflammatory agent to cyclooxygenase-1 and cyclooxygenase-2 enzymes as an application of saturation transfer difference nuclear magnetic resonance. It has been shown that this novel agent is capable of binding to both isoforms of the cyclooxygenase enzymes. It has also been reported that novel agent binds better to cyclooxygenase-2.en_US
dc.description.sponsorshipTurkish Phys Socen_US
dc.description.sponsorshipDUBAP [14-MYO-120]en_US
dc.description.sponsorshipOur special thanks go to DUBAP for funding this project under project No. 14-MYO-120.en_US
dc.identifier.doi10.1139/cjp-2017-0759
dc.identifier.endpage699en_US
dc.identifier.issn0008-4204
dc.identifier.issn1208-6045
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85049601156
dc.identifier.scopusqualityQ3
dc.identifier.startpage693en_US
dc.identifier.urihttps://doi.org/10.1139/cjp-2017-0759
dc.identifier.urihttps://hdl.handle.net/11468/17810
dc.identifier.volume96en_US
dc.identifier.wosWOS:000437293500007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherCanadian Science Publishing, Nrc Research Pressen_US
dc.relation.ispartofCanadian Journal of Physics
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNmren_US
dc.subjectH-1en_US
dc.subjectStd-Nmren_US
dc.subjectCyclooxygenase-1en_US
dc.subjectCyclooxygenase-2en_US
dc.subjectIbuprofenen_US
dc.subjectNsaidsen_US
dc.titleComparison of binding properties of a novel non-steroidal anti-inflammatory agent and ibuprofen to cyclooxygenase-1 and cyclooxygenase-2 enzymes by saturation transfer difference nuclear magnetic resonanceen_US
dc.titleComparison of binding properties of a novel non-steroidal anti-inflammatory agent and ibuprofen to cyclooxygenase-1 and cyclooxygenase-2 enzymes by saturation transfer difference nuclear magnetic resonance
dc.typeConference Objecten_US

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