Use of C-type natriuretic peptide as an indicator in detection of inducible peripheral ischemia
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Society of Cardivascular Surgery
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu deneysel çalışmada, periferik iskeminin başında kritik saatlerdeki plazma C-tip natriüretik peptid (CNP) düzeylerindeki değişiklikler değerlendirildi.Çalışma planı: Çalışmaya 40 adet Sprague-Dawley cinsi erkek sıçan (8-12 haftalık ve ortalama ağırlıkları 230±30 g) alındı. Her grupta 10 sıçan olacak şekilde dört grup oluşturuldu: kontrol grubu, grup 1, grup 2 ve grup 3. Kontrol grubunda herhangi bir işlem yapılmadan başlangıç plazma CNP değeri tespit edilirken, grup 1'de periferik iskeminin ikinci saatinde plazma CNP düzeyine bakıldı. Grup 2'de periferik iskeminin beşinci saatindeki plazma CNP düzeyi tespit edilirken, plazma CNP düzeyleri grup 3'te periferik iskeminin sekizinci saatinde belirlendi.Bul gu lar: Başlangıç plazma CNP düzeyi kontrol grubunda 0.285±0.011 pmol/L olarak tespit edildi. Periferik iskemi oluşturulan sıçanlarda, plazma CNP düzeyinin zamana bağlı olarak anlamlı olarak arttığı tespit edildi (p<0.05). Plazma CNP düzeyleri grup 1, 2 ve 3'de sırasıyla 0.350±0.015, 0.486±0.084 ve 0.534±0.048 pmol/L olarak tespit edildi. So nuç: Endotel kaynaklı vazodilatatör olan plazma CNP zamana bağlı olarak iskemik dokularda hücresel yanıt ile ilişkilidir.
Background: In this experimental study, alterations in plasma C-type natriuretic peptide (CNP) levels were evaluated during the critical initial hours of peripheral ischemia. Methods: Forty male Sprague-Dawley type rats (aged 8 to 12 weeks, weighing 230±30 g) were included in the study. Four groups were created with 10 rats namely control group, group 1, group 2, and group 3. Baseline plasma CNP levels were detected in the control group without any intervention, while the plasma CNP levels were determined in the second hour of peripheral ischemia in group 1. Plasma CNP levels were determined in the fifth hour of peripheral ischemia for group 2, whereas plasma CNP levels were determined in group 3 at the eighth hour of peripheral ischemia. Results: The baseline plasma CNP levels were 0.285±0.011 pmol/L in the control group. In rats with peripheral ischemia, a significant time-dependent increase was detected in plasma levels of CNP (p<0.05). The plasma CNP levels were detected as 0.350±0.015, 0.486±0.084, and 0.534±0.048 pmol/L in group 1, 2, and 3 respectively. Conclusion: Plasma CNP, an endothelium-derived vasodilator, is associated with the cellular response in ischemic tissues in a time-dependent manner.
Background: In this experimental study, alterations in plasma C-type natriuretic peptide (CNP) levels were evaluated during the critical initial hours of peripheral ischemia. Methods: Forty male Sprague-Dawley type rats (aged 8 to 12 weeks, weighing 230±30 g) were included in the study. Four groups were created with 10 rats namely control group, group 1, group 2, and group 3. Baseline plasma CNP levels were detected in the control group without any intervention, while the plasma CNP levels were determined in the second hour of peripheral ischemia in group 1. Plasma CNP levels were determined in the fifth hour of peripheral ischemia for group 2, whereas plasma CNP levels were determined in group 3 at the eighth hour of peripheral ischemia. Results: The baseline plasma CNP levels were 0.285±0.011 pmol/L in the control group. In rats with peripheral ischemia, a significant time-dependent increase was detected in plasma levels of CNP (p<0.05). The plasma CNP levels were detected as 0.350±0.015, 0.486±0.084, and 0.534±0.048 pmol/L in group 1, 2, and 3 respectively. Conclusion: Plasma CNP, an endothelium-derived vasodilator, is associated with the cellular response in ischemic tissues in a time-dependent manner.
Açıklama
Anahtar Kelimeler
C-type natriuretic peptide, Ischemic response, Peripheral ischemia, C-tip natriüretik peptid, Iskemik yanıt, Periferik iskemi
Kaynak
Türk Göğüs Kalp Damar Cerrahisi Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
22
Sayı
3
Künye
Çalışkan, A., Yazıcı, S., Karahan, O., Güçlü, O., Tezcan, O., Demirtaş, S. ve diğerleri. (2014). Use of C-type natriuretic peptide as an indicator in detection of inducible peripheral ischemia. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 22(3), 615-619.
