The Association Between Apolipoprotein E Genetic Polymorphisms and Multiple Sclerosis

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dc.contributor.authorTasdemir, Nebahat
dc.contributor.authorTamam, Yusuf
dc.contributor.authorYalman, Mediha
dc.date.accessioned2024-04-24T17:24:26Z
dc.date.available2024-04-24T17:24:26Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Although the etiology of multiple sclerosis (MS) has not yet been clearly elucidated, MS is a chronic inflammatory disease, in which genetic and environmental factors are involved. The association between apolipoprotein E (APOE) genetic polymorphisms and various neurodegenerative diseases, including MS, is controversial. In the current study, specific APOE genotypes were investigated in patients with MS. Methods: Fifty patients clinically diagnosed with MS and 30 healthy volunteers were included in the study. The APOE genotype was identified via the polymerase chain reaction (PCR) method. The patient and control groups were compared in terms of the frequency of APOE genotypes. Results: The APOE genotype distribution in the patient group was as follows: epsilon 3/epsilon 3, 82.0%; epsilon 3/epsilon 4, 12.0%; and epsilon 2/epsilon 3, 6.0%. There were no significant differences between the patient and control groups with respect to the frequency of APOE genotypes, and APOE epsilon 4 allele carriage (p=0.56). However, the frequency of APOE epsilon 4 allele carriers were significantly higher among male patients (p=0.007). Conclusion: These findings suggest that the APOE genotype has no effect on susceptibility to MS. Further studies with larger sample sizes to be able to include all APOE genotypes are warranted. Identification of genetic factors that may have a role in the etiology of MS will make a substantial contribution to the knowledge of the prevention and treatment of MS.en_US
dc.identifier.doi10.4274/npa.y6232
dc.identifier.endpage115en_US
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue2en_US
dc.identifier.startpage110en_US
dc.identifier.trdizinid156093
dc.identifier.urihttps://doi.org/10.4274/npa.y6232
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/156093
dc.identifier.urihttps://hdl.handle.net/11468/19676
dc.identifier.volume50en_US
dc.identifier.wosWOS:000320972700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectApolipoproteins Een_US
dc.subjectGenotypeen_US
dc.subjectNeurodegenerative Diseaseen_US
dc.titleThe Association Between Apolipoprotein E Genetic Polymorphisms and Multiple Sclerosisen_US
dc.titleThe Association Between Apolipoprotein E Genetic Polymorphisms and Multiple Sclerosis
dc.typeArticleen_US

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