Histopathological changes in the vagina of rats treated neonatally with clomiphene citrate

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dc.contributor.authorÖnen A.
dc.contributor.authorDeveci E.
dc.contributor.authorErdinç M.
dc.date.accessioned2024-04-24T18:44:03Z
dc.date.available2024-04-24T18:44:03Z
dc.date.issued1997
dc.departmentDicle Üniversitesien_US
dc.description.abstractClomiphene citrate is a nonsteroid antiestrogen which is widely used in the therapy of receptor-positive estrogen for the induction of ovulation. Clomiphene citrate was given subcutaneously to newly born rats with daily injections of 100 mg/kg for 5 days. Changes caused by the clomiphene citrate in vaginas of female rats were investigated at 28 and 35 days. Depending upon the effect of the clomiphene citrate, histopathological changes such as papillary development at keratinization, increase in vaginal epithelium, and observation of polygonal shaped nodular cells in stroma were considered as important findings. It should be emphasised that clomiphene citrate used for induction of ovulation caused these abnormalities in the vagina of rats.en_US
dc.identifier.endpage205en_US
dc.identifier.issn0390-6663
dc.identifier.issue4en_US
dc.identifier.pmid9478319
dc.identifier.scopus2-s2.0-0031468794
dc.identifier.scopusqualityQ4
dc.identifier.startpage203en_US
dc.identifier.urihttps://hdl.handle.net/11468/24532
dc.identifier.volume24en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofClinical and Experimental Obstetrics and Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClomiphene Citrateen_US
dc.subjectHistopathological Changesen_US
dc.subjectNeonatal Raten_US
dc.subjectVaginaen_US
dc.titleHistopathological changes in the vagina of rats treated neonatally with clomiphene citrateen_US
dc.titleHistopathological changes in the vagina of rats treated neonatally with clomiphene citrate
dc.typeArticleen_US

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